The effects of optical isomers of fenfluramine and their metabolites, d- and 1-norfenfluramine on the serotonergic system were studied in the nucleus accumbens and hippocampus of freely moving rats by in vivo voltammetry. Both isomers and the metabolites induced a slow, sustained decrease in 5HIAA but only d-fenfluramine and its metabolite, d-norfenfluramine, increased the 5HIAA levels in nucleus accumbens shortly after injection, the increase being greater after the metabolite. No effect could be detected in the hippocampus after the higher dose of d-fenfluramine.
- 5-Hydroxyindoleacetic acid (5-HIAA)
- Nucleus accumbens
- Voltammetry (in vivo)
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience