Different effects of fenfluramine isomers and metabolites on extracellular 5-HIAA in nucleus accumbens and hippocampus of freely moving rats

Maria Grazia De Simoni, Zdzislaw Juraszczyk, Fabio Fodritto, Ada De Luigi, Silvio Garattini

Research output: Contribution to journalArticle

Abstract

The effects of optical isomers of fenfluramine and their metabolites, d- and 1-norfenfluramine on the serotonergic system were studied in the nucleus accumbens and hippocampus of freely moving rats by in vivo voltammetry. Both isomers and the metabolites induced a slow, sustained decrease in 5HIAA but only d-fenfluramine and its metabolite, d-norfenfluramine, increased the 5HIAA levels in nucleus accumbens shortly after injection, the increase being greater after the metabolite. No effect could be detected in the hippocampus after the higher dose of d-fenfluramine.

Original languageEnglish
Pages (from-to)295-299
Number of pages5
JournalEuropean Journal of Pharmacology
Volume153
Issue number2-3
DOIs
Publication statusPublished - Aug 24 1988

Keywords

  • 5-Hydroxyindoleacetic acid (5-HIAA)
  • Fenfluramine
  • Nucleus accumbens
  • Voltammetry (in vivo)

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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