Different effects of glyburide and glipizide on insulin secretion and hepatic glucose production in normal and NIDDM subjects

L. Groop, L. Luzi, A. Melander, P. H. Groop, K. Ratheiser, D. C. Simonson, R. A. DeFronzo

Research output: Contribution to journalArticlepeer-review

Abstract

Glyburide (GB) and glipizide (GZ) differ in their pharmacokinetics, but it is not known whether they also differ in mode of action. To examine this question, 10 young healthy subjects and 6 non-insulin-dependent diabetic (NIDDM) patients participated in each of three studies: 1) infusion of saline for 120 min followed by a 100-min hyperglycemic (124 mg/dl) clamp; 2) 120-min primed continuous infusion of GZ followed by a 100-min hyperglycemic clamp; and 3) 120-min primed continuous infusion of GB followed by a 100-min hyperglycemic clamp. The GB and GZ infusions were continued throughout the hyperglycemic clamp. Similar plasma concentrations of GB and GZ were obtained in both groups. All studies were performed with [3-3H]glucose to allow quantification of hepatic glucose production. When administered under basal conditions of glycemia, the acute phase (0-10 min) of plasma insulin and C-peptide increase in both control and NIDDM subjects was twice as great with GZ compared with GB (P -1·min-1) more effectively than GZ (to 0.40 ± 0.12 vs. 0.82 ± 0.11 mg 1/2 .kg-1·min-1, P

Original languageEnglish
Pages (from-to)1320-1328
Number of pages9
JournalDiabetes
Volume36
Issue number11
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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