Background: Proton pump inhibitors may interfere with the accuracy of the 13C-urea breath test, but little information is available on the effect of standard doses of various proton pump inhibitors on this test. Aim: To evaluate the effect of short-term standard doses of omeprazole, lansoprazole and pantoprazole on the accuracy of the standardized 13C-urea breath test. Methods: A total of 124 patients with Helicobacter pylori infection, diagnosed on the basis of gastric histology, rapid urease test and 13C-urea breath test, were studied. These patients received omeprazole, 20 mg/day, lansoprazole, 30 mg/day, or pantoprazole, 40 mg/day, for 2 weeks according to a randomized protocol, 13C-Urea breath test was repeated on days 4, 7 and 14 while on therapy and 7 days after proton pump inhibitor withdrawal. Results: Of the patients receiving omeprazole and lansoprazole, 30% (12/40) and 20% (8/41), respectively, became 13C-urea breath test negative during therapy, compared with none of the 42 patients treated with pantoprazole (P <0.05). All the false negative 13C-urea breath test results returned to positive within 1 week of drug withdrawal, with a mean recovery to 84.7 ± 15.6% of baseline δ13CO2. Conclusions: Short-term omeprazole and lansoprazole interfere with the 13C-urea breath test, although a return to positive test results invariably occurs within 1 week of proton pump inhibitor withdrawal. In contrast, the accuracy of the 13C-urea breath test does not appear to be significantly impaired by short-term pantoprazole, which therefore may not necessarily be withdrawn before this test.
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)