Different effects of tibolone and low-dose EPT in the management of postmenopausal women with primary headaches

Rossella E. Nappi, Grazia Sances, Arianna Sommacal, Silvia Detaddei, Fabio Facchinetti, Silvano Cristina, Franco Polatti, Giuseppe Nappi

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: The present randomized prospective study aimed to compare the effect of tibolone (T) with conventional low-dose estrogen-progestogen therapy (EPT) administered in a combined continuous regimen on the course of primary headaches in postmenopausal women requesting hormone therapy (HT) for climacteric complaints. DESIGN: Forty women presenting for clinical evaluation of headache (migraine without aura and episodic tension-type headache) were enrolled. The observational period lasted 7 months during which women kept a diary of the clinical characteristics of headache attacks and analgesic use. Climacteric symptoms and both anxiety and depression were also measured. After a 1-month run-in period, women received two different HT regimens: 1 mg 17β-estradiol + 0.5 mg norethisterone acetate (EPT) or 2.5 mg T. Follow-up evaluations were planned after 3 and 6 months of treatment. RESULTS: Although T did not affect the number of days with migraine without aura, it significantly reduced the number of hours during which pain intensity prohibited daily activities (P <0.001) and the number of analgesics (P <0.001) after 3 months. Conventional low-dose EPT administered in a combined continuous regimen was confirmed to have a mild, but negative, effect on the course of migraine without aura by increasing the number of days with head pain (P <0.001) and the number of analgesics (P <0.001). Interestingly, both treatments were effective in the management of episodic tension-type headache, significantly reducing the number of days with head pain, severity, and analgesic consumption. CONCLUSIONS: In postmenopausal headache sufferers, analgesics are more effective in alleviating severe head pain when women are treated with T in comparison with low-dose EPT for climacteric complaints.

Original languageEnglish
Pages (from-to)818-825
Number of pages8
JournalMenopause
Volume13
Issue number5
DOIs
Publication statusPublished - Sep 2006

Keywords

  • Analgesics
  • Hormone therapy
  • Menopause
  • Migraine
  • Tension-type headache
  • Tibolone

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Fingerprint

Dive into the research topics of 'Different effects of tibolone and low-dose EPT in the management of postmenopausal women with primary headaches'. Together they form a unique fingerprint.

Cite this