TY - JOUR
T1 - Different evolutionary rates and epidemic growth of hepatitis B virus genotypes A and D
AU - Zehender, Gianguglielmo
AU - Maddalena, Chiara De
AU - Giambelli, Camilla
AU - Milazzo, Laura
AU - Schiavini, Monica
AU - Bruno, Raffaele
AU - Tanzi, Elisabetta
AU - Galli, Massimo
PY - 2008/10/10
Y1 - 2008/10/10
N2 - The epidemiological history of HBV genotypes A and D and subgenotypes A2 and D3 was studied on 132 isolates drawn between 1980 and 2005 from patients living in a homogenous geographical area. Evolutionary rates and divergence dates were estimated and HBV demographic history was reconstructed by using a statistical approach based on coalescent theory. The evolutionary rate of A2 was significantly lower than that of D3. The growth rate of D3 epidemic was significantly faster than that of A2; both subgenotypes showed a decreasing growth rate from the mid-1980s. Our data suggest that the important discrepancies observed in the evolutionary rates of HBV genotypes A and D may reflect different population dynamics of their epidemics. These results show the usefulness of phylodynamic studies in reconstructing the history of epidemics due to highly variable DNA viruses, and in evaluating the long-term efficacy of prophylactic measures.
AB - The epidemiological history of HBV genotypes A and D and subgenotypes A2 and D3 was studied on 132 isolates drawn between 1980 and 2005 from patients living in a homogenous geographical area. Evolutionary rates and divergence dates were estimated and HBV demographic history was reconstructed by using a statistical approach based on coalescent theory. The evolutionary rate of A2 was significantly lower than that of D3. The growth rate of D3 epidemic was significantly faster than that of A2; both subgenotypes showed a decreasing growth rate from the mid-1980s. Our data suggest that the important discrepancies observed in the evolutionary rates of HBV genotypes A and D may reflect different population dynamics of their epidemics. These results show the usefulness of phylodynamic studies in reconstructing the history of epidemics due to highly variable DNA viruses, and in evaluating the long-term efficacy of prophylactic measures.
KW - Basic reproductive number
KW - Coalescent
KW - HBV
KW - Molecular epidemiology
KW - Molecular evolution
UR - http://www.scopus.com/inward/record.url?scp=52049089442&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=52049089442&partnerID=8YFLogxK
U2 - 10.1016/j.virol.2008.07.009
DO - 10.1016/j.virol.2008.07.009
M3 - Article
C2 - 18715605
AN - SCOPUS:52049089442
VL - 380
SP - 84
EP - 90
JO - Virology
JF - Virology
SN - 0042-6822
IS - 1
ER -