Different expression pattern of cytokine receptors by human osteosarcoma cell lines

Gina Lisignoli, Stefania Toneguzzi, Luca Cattini, Caterina Pozzi, Andrea Facchini

Research output: Contribution to journalArticlepeer-review

Abstract

Cytokine receptor expression in human osteosarcoma cell lines (U2-OS, Saos-2, MG-63) was analyzed by flow cytometry to identify receptors which may interact with osteosarcoma cell growth and that should not be used in a clinical setting. U2-OS, Saos-2, MG-63 and bone marrow stromal cells, that were used as normal controls, constitutively express the FAS and SCFR surface molecules. GM-CSFR is expressed only by U2-OS and Saos-2 cell lines, that are phenotypically less differentiated than MG-63. Different gp130 clones were expressed only by Saos-2 and MG-63 cell lines. IL-2Rγ, IL-7R and 4-1BB were expressed only by Saos-2 cell line. These data add new evidence of receptors that may be activated by autocrine or paracrine cytokines that could induce osteosarcoma cell growth.

Original languageEnglish
Pages (from-to)899-903
Number of pages5
JournalInternational Journal of Oncology
Volume12
Issue number4
Publication statusPublished - Apr 1998

Keywords

  • Cytokine receptors
  • Osteosarcoma cell lines

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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