Abstract
We studied 134 patients with differentiated thyroid cancer and pulmonary metastases. All were treated with total or near total thyroidectomy, radioiodine and L-thyroxine. The prognostic value of the following variables in three groups of patients were evaluated by univariate and multivariate analysis: age at diagnosis, sex, histologic type, tumor extension, cervical lymph node metastases, mediastinic metastases, presence of metastases in distant sites other than lungs (multiple distant metastases) and morphological (chest x-rays) and functional (131I uptake) features of lung metastases. Univariate analysis identified patient age (p <0.0001), morphological and functional features of lung metastases (p <0.0001), presence of multiple distant metastases (p <0.0001) and histologic type (p = 0.04) as significant prognostic factors. Multivariate analysis showed only morphological (p = 0.0014) and functional (p <0.0001) features of lung metastases and the presence of multiple distant metastases (p = 0.01) as significant and independent variables. The data show that early (pre- radiological) scintigraphic diagnosis and 131I therapy of lung metastases appear to be the most important elements in obtaining both a significant improvement in survival rate and a prolonged disease-free time interval in these patients.
| Original language | English |
|---|---|
| Pages (from-to) | 1626-1631 |
| Number of pages | 6 |
| Journal | Journal of Nuclear Medicine |
| Volume | 34 |
| Issue number | 10 |
| Publication status | Published - 1993 |
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ASJC Scopus subject areas
- Radiological and Ultrasound Technology
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Different features of pulmonary metastases in differentiated thyroid cancer : Natural history and multivariate statistical analysis of prognostic variables. / Casara, D.; Rubello, D.; Saladini, G.; Masarotto, G.; Favero, A.; Girelli, M. E.; Busnardo, B.
In: Journal of Nuclear Medicine, Vol. 34, No. 10, 1993, p. 1626-1631.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Different features of pulmonary metastases in differentiated thyroid cancer
T2 - Natural history and multivariate statistical analysis of prognostic variables
AU - Casara, D.
AU - Rubello, D.
AU - Saladini, G.
AU - Masarotto, G.
AU - Favero, A.
AU - Girelli, M. E.
AU - Busnardo, B.
PY - 1993
Y1 - 1993
N2 - We studied 134 patients with differentiated thyroid cancer and pulmonary metastases. All were treated with total or near total thyroidectomy, radioiodine and L-thyroxine. The prognostic value of the following variables in three groups of patients were evaluated by univariate and multivariate analysis: age at diagnosis, sex, histologic type, tumor extension, cervical lymph node metastases, mediastinic metastases, presence of metastases in distant sites other than lungs (multiple distant metastases) and morphological (chest x-rays) and functional (131I uptake) features of lung metastases. Univariate analysis identified patient age (p <0.0001), morphological and functional features of lung metastases (p <0.0001), presence of multiple distant metastases (p <0.0001) and histologic type (p = 0.04) as significant prognostic factors. Multivariate analysis showed only morphological (p = 0.0014) and functional (p <0.0001) features of lung metastases and the presence of multiple distant metastases (p = 0.01) as significant and independent variables. The data show that early (pre- radiological) scintigraphic diagnosis and 131I therapy of lung metastases appear to be the most important elements in obtaining both a significant improvement in survival rate and a prolonged disease-free time interval in these patients.
AB - We studied 134 patients with differentiated thyroid cancer and pulmonary metastases. All were treated with total or near total thyroidectomy, radioiodine and L-thyroxine. The prognostic value of the following variables in three groups of patients were evaluated by univariate and multivariate analysis: age at diagnosis, sex, histologic type, tumor extension, cervical lymph node metastases, mediastinic metastases, presence of metastases in distant sites other than lungs (multiple distant metastases) and morphological (chest x-rays) and functional (131I uptake) features of lung metastases. Univariate analysis identified patient age (p <0.0001), morphological and functional features of lung metastases (p <0.0001), presence of multiple distant metastases (p <0.0001) and histologic type (p = 0.04) as significant prognostic factors. Multivariate analysis showed only morphological (p = 0.0014) and functional (p <0.0001) features of lung metastases and the presence of multiple distant metastases (p = 0.01) as significant and independent variables. The data show that early (pre- radiological) scintigraphic diagnosis and 131I therapy of lung metastases appear to be the most important elements in obtaining both a significant improvement in survival rate and a prolonged disease-free time interval in these patients.
UR - http://www.scopus.com/inward/record.url?scp=0027429811&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027429811&partnerID=8YFLogxK
M3 - Article
C2 - 8410272
AN - SCOPUS:0027429811
VL - 34
SP - 1626
EP - 1631
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
SN - 0161-5505
IS - 10
ER -