Different fetal-neonatal outcomes in siblings born to a mother with Graves-Basedow disease after total thyroidectomy: A case series

Antonio Alberto Zuppa, Paola Sindico, Sabrina Perrone, Chiara Carducci, Eleonora Antichi, Giovanni Alighieri, Francesco Cota, Patrizia Papacci, Maria Pia De Carolis, Costantino Romagnoli, Valentina Cardiello

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Introduction. We describe three different fetal or neonatal outcomes in the offspring of a mother who had persistent circulating thyrotropin receptor antibodies despite having undergone a total thyroidectomy several years before. Case presentation. The three different outcomes were an intrauterine death, a mild and transient fetal and neonatal hyperthyroidism and a severe fetal and neonatal hyperthyroidism that required specific therapy. Conclusions. The three cases are interesting because of the different outcomes, the absence of a direct correlation between thyrotropin receptor antibody levels and clinical signs, and the persistence of thyrotropin receptor antibodies several years after a total thyroidectomy.

Original languageEnglish
Article number59
JournalJournal of Medical Case Reports
Volume4
DOIs
Publication statusPublished - 2010

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Thyrotropin Receptors
Graves Disease
Thyroidectomy
Hyperthyroidism
Antibodies
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Different fetal-neonatal outcomes in siblings born to a mother with Graves-Basedow disease after total thyroidectomy : A case series. / Zuppa, Antonio Alberto; Sindico, Paola; Perrone, Sabrina; Carducci, Chiara; Antichi, Eleonora; Alighieri, Giovanni; Cota, Francesco; Papacci, Patrizia; De Carolis, Maria Pia; Romagnoli, Costantino; Cardiello, Valentina.

In: Journal of Medical Case Reports, Vol. 4, 59, 2010.

Research output: Contribution to journalArticle

Zuppa, AA, Sindico, P, Perrone, S, Carducci, C, Antichi, E, Alighieri, G, Cota, F, Papacci, P, De Carolis, MP, Romagnoli, C & Cardiello, V 2010, 'Different fetal-neonatal outcomes in siblings born to a mother with Graves-Basedow disease after total thyroidectomy: A case series', Journal of Medical Case Reports, vol. 4, 59. https://doi.org/10.1186/1752-1947-4-59
Zuppa, Antonio Alberto ; Sindico, Paola ; Perrone, Sabrina ; Carducci, Chiara ; Antichi, Eleonora ; Alighieri, Giovanni ; Cota, Francesco ; Papacci, Patrizia ; De Carolis, Maria Pia ; Romagnoli, Costantino ; Cardiello, Valentina. / Different fetal-neonatal outcomes in siblings born to a mother with Graves-Basedow disease after total thyroidectomy : A case series. In: Journal of Medical Case Reports. 2010 ; Vol. 4.
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