Different GH responsiveness to repeated GHRH administration in normal children and adults

A. Sartorio, A. Spada, F. Morabito, G. Faglia

Research output: Contribution to journalArticle

Abstract

It has been previously reported that repeated GHRH administration leads to a reduction in growth hormone responses in adults. In order to verify if this regulatory mechanism is also operating in children, we compared GH secretory responses to repeated GHRH in normal children and adults. The administration of the first GHRH bolus caused a marked GH rise (expressed as net incremental area under the curve, nAUC ± SE) both in children (GH nAUC: 1184 ± 216 ng/ml/h) and in adults (GH nAUC: 701.2 ± 90 ng/ml/h). The second GHRH bolus induced a different pattern of GH secretion in the two groups. In children the peptide determined a clear GH rise (GH nAUC: 518 ± 147 ng/ml/h), while in adults the second GHRH injection was uneffective (GH nAUC: 21 ± 20 ng/ml/h). These preliminary results indicate that in children repeated GHRH administration does not induce refractoriness to GHRH action, suggesting different regulatory mechanism of GH secretion in normal children and adults.

Original languageEnglish
Pages (from-to)727-729
Number of pages3
JournalJournal of Endocrinological Investigation
Volume11
Issue number10
DOIs
Publication statusPublished - 1988

Fingerprint

Growth Hormone
Area Under Curve
Peptides
Injections

Keywords

  • Adults
  • children
  • GH
  • GHRH

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Different GH responsiveness to repeated GHRH administration in normal children and adults. / Sartorio, A.; Spada, A.; Morabito, F.; Faglia, G.

In: Journal of Endocrinological Investigation, Vol. 11, No. 10, 1988, p. 727-729.

Research output: Contribution to journalArticle

@article{a80053c98bd647e5941094dede6c7ba1,
title = "Different GH responsiveness to repeated GHRH administration in normal children and adults",
abstract = "It has been previously reported that repeated GHRH administration leads to a reduction in growth hormone responses in adults. In order to verify if this regulatory mechanism is also operating in children, we compared GH secretory responses to repeated GHRH in normal children and adults. The administration of the first GHRH bolus caused a marked GH rise (expressed as net incremental area under the curve, nAUC ± SE) both in children (GH nAUC: 1184 ± 216 ng/ml/h) and in adults (GH nAUC: 701.2 ± 90 ng/ml/h). The second GHRH bolus induced a different pattern of GH secretion in the two groups. In children the peptide determined a clear GH rise (GH nAUC: 518 ± 147 ng/ml/h), while in adults the second GHRH injection was uneffective (GH nAUC: 21 ± 20 ng/ml/h). These preliminary results indicate that in children repeated GHRH administration does not induce refractoriness to GHRH action, suggesting different regulatory mechanism of GH secretion in normal children and adults.",
keywords = "Adults, children, GH, GHRH",
author = "A. Sartorio and A. Spada and F. Morabito and G. Faglia",
year = "1988",
doi = "10.1007/BF03350930",
language = "English",
volume = "11",
pages = "727--729",
journal = "Journal of Endocrinological Investigation",
issn = "0391-4097",
publisher = "Springer International Publishing",
number = "10",

}

TY - JOUR

T1 - Different GH responsiveness to repeated GHRH administration in normal children and adults

AU - Sartorio, A.

AU - Spada, A.

AU - Morabito, F.

AU - Faglia, G.

PY - 1988

Y1 - 1988

N2 - It has been previously reported that repeated GHRH administration leads to a reduction in growth hormone responses in adults. In order to verify if this regulatory mechanism is also operating in children, we compared GH secretory responses to repeated GHRH in normal children and adults. The administration of the first GHRH bolus caused a marked GH rise (expressed as net incremental area under the curve, nAUC ± SE) both in children (GH nAUC: 1184 ± 216 ng/ml/h) and in adults (GH nAUC: 701.2 ± 90 ng/ml/h). The second GHRH bolus induced a different pattern of GH secretion in the two groups. In children the peptide determined a clear GH rise (GH nAUC: 518 ± 147 ng/ml/h), while in adults the second GHRH injection was uneffective (GH nAUC: 21 ± 20 ng/ml/h). These preliminary results indicate that in children repeated GHRH administration does not induce refractoriness to GHRH action, suggesting different regulatory mechanism of GH secretion in normal children and adults.

AB - It has been previously reported that repeated GHRH administration leads to a reduction in growth hormone responses in adults. In order to verify if this regulatory mechanism is also operating in children, we compared GH secretory responses to repeated GHRH in normal children and adults. The administration of the first GHRH bolus caused a marked GH rise (expressed as net incremental area under the curve, nAUC ± SE) both in children (GH nAUC: 1184 ± 216 ng/ml/h) and in adults (GH nAUC: 701.2 ± 90 ng/ml/h). The second GHRH bolus induced a different pattern of GH secretion in the two groups. In children the peptide determined a clear GH rise (GH nAUC: 518 ± 147 ng/ml/h), while in adults the second GHRH injection was uneffective (GH nAUC: 21 ± 20 ng/ml/h). These preliminary results indicate that in children repeated GHRH administration does not induce refractoriness to GHRH action, suggesting different regulatory mechanism of GH secretion in normal children and adults.

KW - Adults

KW - children

KW - GH

KW - GHRH

UR - http://www.scopus.com/inward/record.url?scp=0024241419&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024241419&partnerID=8YFLogxK

U2 - 10.1007/BF03350930

DO - 10.1007/BF03350930

M3 - Article

C2 - 3148001

AN - SCOPUS:0024241419

VL - 11

SP - 727

EP - 729

JO - Journal of Endocrinological Investigation

JF - Journal of Endocrinological Investigation

SN - 0391-4097

IS - 10

ER -