Different Human Papillomavirus genotypes in ano-genital lesions

Maria Lucia Caruso, A. M. Valentini

Research output: Contribution to journalArticlepeer-review


In order to verify the frequency and physical state of some viral strains of Human Papillomavirus (HPV) in ano-genital lesions, two-hundred and four specimens were studied. HPV/DNA was detected by using non isotopic in situ hybridization method. HPV-DNA was found in 25 lesions. The integrated pattern of HPV types 16/18 was found only in invasive carcinomas, the episomic one in all high risk lesions, never in invasive carcinomas. The low oncogenic risk genotypes 6/11 were detected only in condylomata acuminata, the high oncogenic risk genotypes 16/18 were found not only in cervial intra-epithelial and ivasive lesions, but also in a condyloma acuminatum. Our findings confirm the importance of the viral genotypes in the evaluatin of the risk for malignancy. Therefore, the detection of a high risk viral genotype, independently of its physical state, can evoke the ghost of the malignancy also in a low risk cervial lesion.

Original languageEnglish
Pages (from-to)3049-3053
Number of pages5
JournalAnticancer Research
Issue number4 B
Publication statusPublished - 1999


  • Episomal pattern
  • Genotype
  • Human papillomavirus
  • Integrated pattern
  • Mixed pattern

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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