Abstract
In order to characterize the effector mechanism of ‘in vitro’ lymphocytotoxicity against isolated rabbit liver cells in acute viral hepatitis (AVH). the test was performed in 4 patients with type A, in 8 with type B. and in 2 patients with non-A non-B AVH: (a) using peripheral blood lymphocytes; (b) after enzymatic digestion of the surface membrane immunoglobulins of these lymphocytes, and (c) as in b with addition of patients’ sera. 78.5% of the patients had an elevated cytotoxicity which did not change when the lymphocytes were treated as in b and c. Only the 2 patients which progressed to chronicity had an elevated cytotoxicity which disappeared after enzymatic exposure and reappeared with the addition of patients’ sera. The results suggest that ‘in vitro’ cytotoxicity in recovering AVH is not antibody dependent, but probably of spontaneous type. On the contrary an antibodydependent cytotoxicity is present in the 2 cases of AVH who progressed to chronicity.
| Original language | English |
|---|---|
| Pages (from-to) | 229-238 |
| Number of pages | 10 |
| Journal | Digestion |
| Volume | 22 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1981 |
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Keywords
- Acute viral hepatitis
- Antibody-dependent cellmediated cytotoxicity
- Chronic active hepatitis
- K lymphocytes
- NK lymphocytes
- Spontaneous cell-mediated cytotoxicity
ASJC Scopus subject areas
- Gastroenterology
Cite this
Different mechanisms of ‘in vitro’ lymphocytotoxicity against isolated rabbit hepatocytes during the course of acute viral hepatitis. / Stefanini, G. F.; Bernardi, M.; Miglio, F.; Mariani, E.; Chiodo, F.; Facchini, A.; Labò, G.; Gasbarrini, G.
In: Digestion, Vol. 22, No. 5, 1981, p. 229-238.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Different mechanisms of ‘in vitro’ lymphocytotoxicity against isolated rabbit hepatocytes during the course of acute viral hepatitis
AU - Stefanini, G. F.
AU - Bernardi, M.
AU - Miglio, F.
AU - Mariani, E.
AU - Chiodo, F.
AU - Facchini, A.
AU - Labò, G.
AU - Gasbarrini, G.
PY - 1981
Y1 - 1981
N2 - In order to characterize the effector mechanism of ‘in vitro’ lymphocytotoxicity against isolated rabbit liver cells in acute viral hepatitis (AVH). the test was performed in 4 patients with type A, in 8 with type B. and in 2 patients with non-A non-B AVH: (a) using peripheral blood lymphocytes; (b) after enzymatic digestion of the surface membrane immunoglobulins of these lymphocytes, and (c) as in b with addition of patients’ sera. 78.5% of the patients had an elevated cytotoxicity which did not change when the lymphocytes were treated as in b and c. Only the 2 patients which progressed to chronicity had an elevated cytotoxicity which disappeared after enzymatic exposure and reappeared with the addition of patients’ sera. The results suggest that ‘in vitro’ cytotoxicity in recovering AVH is not antibody dependent, but probably of spontaneous type. On the contrary an antibodydependent cytotoxicity is present in the 2 cases of AVH who progressed to chronicity.
AB - In order to characterize the effector mechanism of ‘in vitro’ lymphocytotoxicity against isolated rabbit liver cells in acute viral hepatitis (AVH). the test was performed in 4 patients with type A, in 8 with type B. and in 2 patients with non-A non-B AVH: (a) using peripheral blood lymphocytes; (b) after enzymatic digestion of the surface membrane immunoglobulins of these lymphocytes, and (c) as in b with addition of patients’ sera. 78.5% of the patients had an elevated cytotoxicity which did not change when the lymphocytes were treated as in b and c. Only the 2 patients which progressed to chronicity had an elevated cytotoxicity which disappeared after enzymatic exposure and reappeared with the addition of patients’ sera. The results suggest that ‘in vitro’ cytotoxicity in recovering AVH is not antibody dependent, but probably of spontaneous type. On the contrary an antibodydependent cytotoxicity is present in the 2 cases of AVH who progressed to chronicity.
KW - Acute viral hepatitis
KW - Antibody-dependent cellmediated cytotoxicity
KW - Chronic active hepatitis
KW - K lymphocytes
KW - NK lymphocytes
KW - Spontaneous cell-mediated cytotoxicity
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U2 - 10.1159/000198662
DO - 10.1159/000198662
M3 - Article
VL - 22
SP - 229
EP - 238
JO - Digestion
JF - Digestion
SN - 0012-2823
IS - 5
ER -