Different methylation and MicroRNA expression pattern in male and female familial breast cancer

Rosamaria Pinto, Brunella Pilato, Laura Ottini, Rossana Lambo, Giovanni Simone, Angelo Paradiso, Stefania Tommasi

Research output: Contribution to journalArticle

Abstract

Epigenetic regulation, has been very scarcely explored in familial breast cancer (BC). In the present study RASSF1A and RAR beta promoter methylation and miR17, miR21, miR 124, and let-7a expression were investigated to highlight possible differences of epigenetic regulation between male and female familial BC, also in comparison with sporadic BC. These epigenetic alterations were studied in 56 familial BC patients (27 males and 29 females) and in 16 female sporadic cases. RASSF1A resulted more frequently methylated in men than women (76% vs. 28%, respectively, P=0.0001), while miR17 and let-7a expression frequency was higher in women than in men (miR17: 66% in women vs. 41% in men, P

Original languageEnglish
Pages (from-to)1264-1269
Number of pages6
JournalJournal of Cellular Physiology
Volume228
Issue number6
DOIs
Publication statusPublished - Jun 2013

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Physiology

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