Different outcomes of the reperfused myocardium: Insights into the comments of stunning and hibernation

R. Ferrari, C. Ceconi, S. Curello, M. Benigno, G. La Canna, P. Pepi, F. Ferrari, O. Visioli

Research output: Contribution to journalArticle

Abstract

There are several potential outcomes of myocardial ischaemia. When ischaemia is severe and prolonged, irreversible damage occurs and there is no recovery of contractile function. Interventions aimed at reducing mechanical activity and oxygen demand either before ischaemia or during reperfusion have been shown to delay the onset of ischaemic damage and to improve recovery during reperfusion. When myocardial ischaemia is less severe but still prolonged, myocytes may remain viable but exhibit depressed contractile function. Under these conditions, reperfusion restores complete contractile performance. This type of ischaemia leading to a reversible, chronic left ventricular dysfunction has been termed 'hibernating myocardium'. It is important clinically recognize hibernation as reperfusion of hibernating myocardium by angioplasty or heart surgery restores contraction and this correlates with long term survival. A third possible outcome after a short period of myocardial ischaemia is a transient post-ischaemic ventricular dysfunction, a situation termed 'stunned myocardium'.

Original languageEnglish
JournalInternational Journal of Cardiology
Volume65
Issue numberSUPPL. 1
DOIs
Publication statusPublished - May 29 1998

Keywords

  • Hibernation
  • Left ventricular dysfunction
  • Myocardial ischemia
  • Stunning

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Ferrari, R., Ceconi, C., Curello, S., Benigno, M., La Canna, G., Pepi, P., Ferrari, F., & Visioli, O. (1998). Different outcomes of the reperfused myocardium: Insights into the comments of stunning and hibernation. International Journal of Cardiology, 65(SUPPL. 1). https://doi.org/10.1016/S0167-5273(98)00058-8