Different patterns of cardiac sympathetic denervation in tremor-type compared to akinetic-rigid-type Parkinson's disease: Molecular imaging with 123I-MIBG

A. Chiaravalloti, A. Stefani, M. Tavolozza, M. Pierantozzi, D. Di Biagio, E. Olivola, B. Di Pietro, M. Stampanoni, R. Danieli, G. Simonetti, P. Stanzione, Orazio Schillaci

Research output: Contribution to journalArticle

Abstract

The aim of this study was to evaluate the correlation between the clinical motor phenotypes of Parkinson's disease (PD) and 123I-MIBG myocardial uptake. In total, 53 patients with PD [31 males and 22 females, mean age 62±10 years; 19 Hoehn & Yahr (H&Y) stage 1, 9 stage 1.5, 15 stage 2 and 10 at stage 3] were examined and subdivided into different clinical forms on the basis of dominance of resting tremor (n=19, TDT) and bradykinesia plus rigidity (n=34, ART). This status was correlated with the semi-quantitative analysis of 123I-MIBG myocardial uptake. An age-matched control group of 18 patients was recruited (8 males and 10 females, mean age 62.4±16.3 years). 123I-MIBG myocardial uptake significantly correlated with disease duration in early (r2=0.1894; P=0.0028) and delayed images (r2=0.1795; P=0.0037) in PD patients, while no correlation was found when considering age at examination, UPDRS III motor examination section score and H&Y score. PD patients showed a reduced 123I-MIBG myocardial uptake compared to the control group in early (P=0.0026) and delayed images (P=0.0040), and 123I-MIBG myocardial uptake was significantly lower in delayed images in TDT patients compared with ART patients (P=0.0167). A decrease was detected in the heart-to-mediastinum (H/M) ratio in delayed images compared to that of the early images in TDT patients (P=0.0040) and in the whole PD population (P=0.0012), while no differences were found in ART patients (P=0.1043). The results of the present study revealed that the cardiac sympathetic system is more severely impaired in TDT than in ART patients and 123I-MIBG molecular imaging has the potential help in improving therapeutic planning in these patients.

Original languageEnglish
Pages (from-to)1337-1342
Number of pages6
JournalMolecular Medicine Reports
Volume6
Issue number6
DOIs
Publication statusPublished - Dec 2012

Keywords

  • I-MIBG
  • Akinetic rigid type
  • Parkinson's disease
  • Sympathetic system
  • Tremor-type

ASJC Scopus subject areas

  • Biochemistry
  • Cancer Research
  • Genetics
  • Molecular Biology
  • Molecular Medicine
  • Oncology

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    Chiaravalloti, A., Stefani, A., Tavolozza, M., Pierantozzi, M., Di Biagio, D., Olivola, E., Di Pietro, B., Stampanoni, M., Danieli, R., Simonetti, G., Stanzione, P., & Schillaci, O. (2012). Different patterns of cardiac sympathetic denervation in tremor-type compared to akinetic-rigid-type Parkinson's disease: Molecular imaging with 123I-MIBG. Molecular Medicine Reports, 6(6), 1337-1342. https://doi.org/10.3892/mmr.2012.1104