TY - JOUR
T1 - Different patterns of heparin resistance
T2 - Therapeutic implications
AU - Ranucci, Marco
AU - Isgrò, Giuseppe
AU - Cazzaniga, Anna
AU - Ditta, Antonio
AU - Boncilli, Alessandra
AU - Cotza, Mauro
AU - Carboni, Giovanni
AU - Brozzi, Simonetta
PY - 2002
Y1 - 2002
N2 - Heparin resistance (HR) during cardiac operations is a common feature. Its aetiology often recognizes a decrease in circulating antithrombin III (AT III) due to a preoperative heparin treatment. Nevertheless, some papers high-lighted the existence of HR in patients with normal values of AT III. This paper was designed in order to identify this subgroup of AT III-independent heparin-resistant patients. Five hundred consecutive patients scheduled for coronary revascularization with cardiopulmonary bypass were enrolled in this prospective trial. HR was identified in 104 (20.8%) patients. Thirty-six of them (7.2% of the total population) had a preoperative AT III activity ≥100%, and were defined as AT III-independent heparin-resistant patients. This subgroup significantly differs from the AT III-dependent heparin-resistant group being affected by a less severe degree of HR and including less patients pretreated with heparin. Unlike the other heparin-resistant patients, these subjects do not respond to AT III supplementation aimed at reaching supranormal AT III activity values.
AB - Heparin resistance (HR) during cardiac operations is a common feature. Its aetiology often recognizes a decrease in circulating antithrombin III (AT III) due to a preoperative heparin treatment. Nevertheless, some papers high-lighted the existence of HR in patients with normal values of AT III. This paper was designed in order to identify this subgroup of AT III-independent heparin-resistant patients. Five hundred consecutive patients scheduled for coronary revascularization with cardiopulmonary bypass were enrolled in this prospective trial. HR was identified in 104 (20.8%) patients. Thirty-six of them (7.2% of the total population) had a preoperative AT III activity ≥100%, and were defined as AT III-independent heparin-resistant patients. This subgroup significantly differs from the AT III-dependent heparin-resistant group being affected by a less severe degree of HR and including less patients pretreated with heparin. Unlike the other heparin-resistant patients, these subjects do not respond to AT III supplementation aimed at reaching supranormal AT III activity values.
UR - http://www.scopus.com/inward/record.url?scp=0036244741&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036244741&partnerID=8YFLogxK
U2 - 10.1191/0267659102pf562oa
DO - 10.1191/0267659102pf562oa
M3 - Article
C2 - 12017388
AN - SCOPUS:0036244741
VL - 17
SP - 199
EP - 204
JO - Perfusion
JF - Perfusion
SN - 0267-6591
IS - 3
ER -