Different patterns of in vivo pro-oxidant states in a set of cancer- or aging-related genetic diseases

Ana Lloret, Rita Calzone, Christina Dunster, Paola Manini, Marco d'Ischia, Paolo Degan, Frank J. Kelly, Federico V. Pallardó, Adriana Zatterale, Giovanni Pagano

Research output: Contribution to journalArticle

Abstract

A comparative evaluation is reported of pro-oxidant states in 82 patients with ataxia telangectasia (AT), Bloom syndrome (BS), Down syndrome (DS), Fanconi anemia (FA), Werner syndrome (WS), and xeroderma pigmentosum (XP) vs 98 control donors. These disorders display cancer proneness, and/or early aging, and/or other clinical features. The measured analytes were: (a) leukocyte and urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG), (b) blood glutathione (GSSG and GSH), (c) plasma glyoxal (Glx) and methylglyoxal (MGlx), and (d) some plasma antioxidants [uric acid (UA) and ascorbic acid (AA)]. Leukocyte 8-OHdG levels ranked as follows: WS > BS ≈ FA ≈ XP > DS ≈ AT ≈ controls. Urinary 8-OHdG levels were significantly increased in a total of 22 patients with BS, FA, or XP vs 47 controls. The GSSG:GSH ratio was significantly increased in patients with WS and in young (≤ 15 years) patients with DS or with FA and decreased in older patients with DS or FA and in AT, BS, and XP patients. The plasma levels of Glx and/or MGlx were significantly increased in patients with WS, FA, and DS. The UA and AA levels were significantly increased in WS and DS patients, but not in AT, FA, BS, nor XP patients. Rationale for chemoprevention trials is discussed.

Original languageEnglish
Pages (from-to)495-503
Number of pages9
JournalFree Radical Biology and Medicine
Volume44
Issue number4
DOIs
Publication statusPublished - Feb 15 2008

Keywords

  • Antioxidants
  • Cancer-prone diseases
  • Chromosomal instability
  • DNA damage
  • Oxidative stress

ASJC Scopus subject areas

  • Medicine(all)
  • Toxicology
  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Different patterns of in vivo pro-oxidant states in a set of cancer- or aging-related genetic diseases'. Together they form a unique fingerprint.

  • Cite this

    Lloret, A., Calzone, R., Dunster, C., Manini, P., d'Ischia, M., Degan, P., Kelly, F. J., Pallardó, F. V., Zatterale, A., & Pagano, G. (2008). Different patterns of in vivo pro-oxidant states in a set of cancer- or aging-related genetic diseases. Free Radical Biology and Medicine, 44(4), 495-503. https://doi.org/10.1016/j.freeradbiomed.2007.10.046