Different rates of autoreactivity in patients with recurrent idiopathic angioedema associated or not with wheals

A. Tedeschi, R. Asero, M. Lorini, A. V. Marzano, M. Cugno

Research output: Contribution to journalArticle

Abstract

Background: The pathophysiology and triggers of idiopathic nonhistaminergic angioedema are unclear. This study aimed to assess autoreactivity in recurrent idiopathic angioedema associated or not with wheals. Methods: The study population comprised 19 patients with recurrent idiopathic nonhistaminergic angioedema without wheals, 38 patients with angioedema and chronic urticaria (CU), and 52 patients with CU without angioedema. Twenty healthy individuals served as controls. Autoreactivity was evaluated in vivo using the autologous serum skin test (ASST) and in vitro by measuring serum-induced basophil histamine release (BHR). Results: ASST results were negative in all patients with idiopathic angioedema without wheals and in healthy controls and positive in 29 of the 38 patients with angioedema and CU (76.3%) and in 26 of the 52 patients with CU without angioedema (50%) (P

Keywords

  • Autologous serum skin test. autoreactivity. basophil histamine release. idiopathic angioedema. chronic urticaria

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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