Different responsiveness of normal and leukemic hemopoietic cells to Esorubicin

G. P. Bagnara, P. Rocchi, G. Zauli, L. Vitale, G. Licia, R. Damiano, G. Paolucci

Research output: Contribution to journalArticle

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Abstract

The effect of different Esorubicin concentrations (10-7 M to 10-10 M) has been tested on the in vitro growth of human normal hemopoietic progenitor cells and of three leukemic cell lines (K562, U 937, HL60). The highest drug concentration completely abolished both normal and leukemic proliferation. Lower doses of Esorubicin failed to induce any morphological or phenotypic differentiation of leukemic cell lines. A 24 h pretreatment of the cells with 10-9 M Esorubicin enhanced the in vitro proliferation of normal early myeloid progenitor cells, whereas it did not affect leukemic, myelomonocytic cell proliferation.

Original languageEnglish
Pages (from-to)1303-1306
Number of pages4
JournalAnticancer Research
Volume8
Issue number6
Publication statusPublished - 1988

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Myeloid Progenitor Cells
Cell Line
Stem Cells
Cell Proliferation
Growth
Pharmaceutical Preparations
esorubicin
In Vitro Techniques

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Bagnara, G. P., Rocchi, P., Zauli, G., Vitale, L., Licia, G., Damiano, R., & Paolucci, G. (1988). Different responsiveness of normal and leukemic hemopoietic cells to Esorubicin. Anticancer Research, 8(6), 1303-1306.

Different responsiveness of normal and leukemic hemopoietic cells to Esorubicin. / Bagnara, G. P.; Rocchi, P.; Zauli, G.; Vitale, L.; Licia, G.; Damiano, R.; Paolucci, G.

In: Anticancer Research, Vol. 8, No. 6, 1988, p. 1303-1306.

Research output: Contribution to journalArticle

Bagnara, GP, Rocchi, P, Zauli, G, Vitale, L, Licia, G, Damiano, R & Paolucci, G 1988, 'Different responsiveness of normal and leukemic hemopoietic cells to Esorubicin', Anticancer Research, vol. 8, no. 6, pp. 1303-1306.
Bagnara GP, Rocchi P, Zauli G, Vitale L, Licia G, Damiano R et al. Different responsiveness of normal and leukemic hemopoietic cells to Esorubicin. Anticancer Research. 1988;8(6):1303-1306.
Bagnara, G. P. ; Rocchi, P. ; Zauli, G. ; Vitale, L. ; Licia, G. ; Damiano, R. ; Paolucci, G. / Different responsiveness of normal and leukemic hemopoietic cells to Esorubicin. In: Anticancer Research. 1988 ; Vol. 8, No. 6. pp. 1303-1306.
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