Different responsiveness of normal and leukemic hemopoietic cells to Esorubicin

G. P. Bagnara, P. Rocchi, G. Zauli, L. Vitale, G. Licia, R. Damiano, G. Paolucci

Research output: Contribution to journalArticle

Abstract

The effect of different Esorubicin concentrations (10-7 M to 10-10 M) has been tested on the in vitro growth of human normal hemopoietic progenitor cells and of three leukemic cell lines (K562, U 937, HL60). The highest drug concentration completely abolished both normal and leukemic proliferation. Lower doses of Esorubicin failed to induce any morphological or phenotypic differentiation of leukemic cell lines. A 24 h pretreatment of the cells with 10-9 M Esorubicin enhanced the in vitro proliferation of normal early myeloid progenitor cells, whereas it did not affect leukemic, myelomonocytic cell proliferation.

Original languageEnglish
Pages (from-to)1303-1306
Number of pages4
JournalAnticancer Research
Volume8
Issue number6
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Bagnara, G. P., Rocchi, P., Zauli, G., Vitale, L., Licia, G., Damiano, R., & Paolucci, G. (1988). Different responsiveness of normal and leukemic hemopoietic cells to Esorubicin. Anticancer Research, 8(6), 1303-1306.