Different role of secretory IgA in the pathogenesis of RAST-positive and RAST-negative atopic dermatitis

A. Plebani, V. Monafo, M. Cespa, A. Giannetti, A. G. Ugazio

Research output: Contribution to journalArticle

Abstract

Secretory-IgA (SIgA) concentrations were determined in whole saliva, unstimulated or stimulated by lemon juice, of thirty-eight children with atopic dermatitis, which comprised three adolescents, sixteen with IgE detected by RAST to one or more common allergen and twenty-two without specific IgE by RAST. There were thirty healthy controls matched for age and sex. The mean amount of total IgE was significantly greater in the RAST-positive than in the RAST-negative group. The mean SIgA concentration in unstimulated saliva of the RAST-positive atopic dermatitis group was less than that of the RAST-negative atopic dermatitis group and control groups, though the mean concentrations of SIgA of stimulated saliva were not significantly different in the three groups. It is suggested that the pathogenesis of atopic dermatitis may differ in children with or without specific-IgE antibodies; in those who were RAST-positive deficient exclusion of allergen by the intestinal barrier contributed to the pathogenesis, but not in those who were RAST-negative.

Original languageEnglish
Pages (from-to)403-407
Number of pages5
JournalClinical Allergy
Volume12
Issue number4
Publication statusPublished - 1982

Fingerprint

Secretory Immunoglobulin A
Atopic Dermatitis
Immunoglobulin E
Saliva
Allergens
Control Groups
Antibodies

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Different role of secretory IgA in the pathogenesis of RAST-positive and RAST-negative atopic dermatitis. / Plebani, A.; Monafo, V.; Cespa, M.; Giannetti, A.; Ugazio, A. G.

In: Clinical Allergy, Vol. 12, No. 4, 1982, p. 403-407.

Research output: Contribution to journalArticle

Plebani, A, Monafo, V, Cespa, M, Giannetti, A & Ugazio, AG 1982, 'Different role of secretory IgA in the pathogenesis of RAST-positive and RAST-negative atopic dermatitis', Clinical Allergy, vol. 12, no. 4, pp. 403-407.
Plebani, A. ; Monafo, V. ; Cespa, M. ; Giannetti, A. ; Ugazio, A. G. / Different role of secretory IgA in the pathogenesis of RAST-positive and RAST-negative atopic dermatitis. In: Clinical Allergy. 1982 ; Vol. 12, No. 4. pp. 403-407.
@article{97b1e87df6004386a582f96dd4186e53,
title = "Different role of secretory IgA in the pathogenesis of RAST-positive and RAST-negative atopic dermatitis",
abstract = "Secretory-IgA (SIgA) concentrations were determined in whole saliva, unstimulated or stimulated by lemon juice, of thirty-eight children with atopic dermatitis, which comprised three adolescents, sixteen with IgE detected by RAST to one or more common allergen and twenty-two without specific IgE by RAST. There were thirty healthy controls matched for age and sex. The mean amount of total IgE was significantly greater in the RAST-positive than in the RAST-negative group. The mean SIgA concentration in unstimulated saliva of the RAST-positive atopic dermatitis group was less than that of the RAST-negative atopic dermatitis group and control groups, though the mean concentrations of SIgA of stimulated saliva were not significantly different in the three groups. It is suggested that the pathogenesis of atopic dermatitis may differ in children with or without specific-IgE antibodies; in those who were RAST-positive deficient exclusion of allergen by the intestinal barrier contributed to the pathogenesis, but not in those who were RAST-negative.",
author = "A. Plebani and V. Monafo and M. Cespa and A. Giannetti and Ugazio, {A. G.}",
year = "1982",
language = "English",
volume = "12",
pages = "403--407",
journal = "Clinical Allergy",
issn = "0009-9090",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Different role of secretory IgA in the pathogenesis of RAST-positive and RAST-negative atopic dermatitis

AU - Plebani, A.

AU - Monafo, V.

AU - Cespa, M.

AU - Giannetti, A.

AU - Ugazio, A. G.

PY - 1982

Y1 - 1982

N2 - Secretory-IgA (SIgA) concentrations were determined in whole saliva, unstimulated or stimulated by lemon juice, of thirty-eight children with atopic dermatitis, which comprised three adolescents, sixteen with IgE detected by RAST to one or more common allergen and twenty-two without specific IgE by RAST. There were thirty healthy controls matched for age and sex. The mean amount of total IgE was significantly greater in the RAST-positive than in the RAST-negative group. The mean SIgA concentration in unstimulated saliva of the RAST-positive atopic dermatitis group was less than that of the RAST-negative atopic dermatitis group and control groups, though the mean concentrations of SIgA of stimulated saliva were not significantly different in the three groups. It is suggested that the pathogenesis of atopic dermatitis may differ in children with or without specific-IgE antibodies; in those who were RAST-positive deficient exclusion of allergen by the intestinal barrier contributed to the pathogenesis, but not in those who were RAST-negative.

AB - Secretory-IgA (SIgA) concentrations were determined in whole saliva, unstimulated or stimulated by lemon juice, of thirty-eight children with atopic dermatitis, which comprised three adolescents, sixteen with IgE detected by RAST to one or more common allergen and twenty-two without specific IgE by RAST. There were thirty healthy controls matched for age and sex. The mean amount of total IgE was significantly greater in the RAST-positive than in the RAST-negative group. The mean SIgA concentration in unstimulated saliva of the RAST-positive atopic dermatitis group was less than that of the RAST-negative atopic dermatitis group and control groups, though the mean concentrations of SIgA of stimulated saliva were not significantly different in the three groups. It is suggested that the pathogenesis of atopic dermatitis may differ in children with or without specific-IgE antibodies; in those who were RAST-positive deficient exclusion of allergen by the intestinal barrier contributed to the pathogenesis, but not in those who were RAST-negative.

UR - http://www.scopus.com/inward/record.url?scp=0019980656&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019980656&partnerID=8YFLogxK

M3 - Article

C2 - 7116617

VL - 12

SP - 403

EP - 407

JO - Clinical Allergy

JF - Clinical Allergy

SN - 0009-9090

IS - 4

ER -