Different sensitivity to hydrochlorothiazide and to potassium-canrenoate among essential hypertensive patients

N. Glorioso, M. G. Melis, P. Manunta, C. Troffa, G. Tonolo, A. Soro, P. Madeddu, A. Pazzola, F. Pala, D. Cusi, G. Bianchi

Research output: Contribution to journalArticle

Abstract

We compared the response of blood pressure (BP) to either K-Canrenoate (K-Can) or hydrochlorothiazide (HCTZ) in 26 mild-to-moderate essential hypertensive in a double-blind, cross-over design over 2 months each. The dose was 12.5 mg o.d. for HCTZ and 50 mg o.d. for K-Can: Dosing was doubled after 1 month if seated diastolic BP was ≥95 mmHg. Eight pts were 'selective responder' to the lowest dose of HCTZ (HCTZ-R), and 6 to K-Can (K-Can-R). Seven pts had their high blood pressure controlled by the highest dose of both drugs and 4 were insensitive to both. One pt dropped out during HCTZ for low plasma K+, and 3 during K-Can (nausea and dizziness: 2 pts; plasma creatinine rise: 1 pt). All these side effects were reverted after drug withdrawal. HCTZ-R and K-Can-R differed for PRA (1.4±0.6 vs 0.8±0.4 Ang I ng/ml/h, p+-K+-Cl- cotransport higher than the HCTZ-R. Their selective response to K-Can suggest a peculiar pathogenetic mechanism underlying their high blood pressure.

Original languageEnglish
Pages (from-to)187-196
Number of pages10
JournalClinical and Experimental Hypertension
Volume15
Issue numberSUPPL. 1
Publication statusPublished - 1993

    Fingerprint

Keywords

  • diuretics
  • Na-K-Cl cotransport
  • plasma rein activity

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Glorioso, N., Melis, M. G., Manunta, P., Troffa, C., Tonolo, G., Soro, A., Madeddu, P., Pazzola, A., Pala, F., Cusi, D., & Bianchi, G. (1993). Different sensitivity to hydrochlorothiazide and to potassium-canrenoate among essential hypertensive patients. Clinical and Experimental Hypertension, 15(SUPPL. 1), 187-196.