TY - JOUR
T1 - Different SEP recovery cycle in adolescent migraineurs with exploding or imploding pain
AU - Iacovelli, Elisa
AU - Tarantino, Samuela
AU - Capuano, Alessandro
AU - De Luca, Massimiliano
AU - De Ranieri, Cristiana
AU - Vigevano, Federico
AU - Arendt-Nielsen, Lars
AU - Valeriani, Massimiliano
PY - 2013/9
Y1 - 2013/9
N2 - Our aim was to investigate whether migraine adolescents with pain directed inside (imploding pain - IP) and outside (exploding pain - EP) the head may have different levels of cortical excitability underlying their migraineous syndrome. Ten migraine children referring prevalent EP (mean age 14.5. ±. 1.4 years, 3 girls, 7 boys), 10 patients with IP (mean age 14.1. ±. 2.2 years, 4 girls, 6 boys), and 13 control subjects (mean age 13. ±. 1.8 years, 6 males, 7 females) participated to the study. The recovery cycle of the somatosensory evoked potentials to electrical median nerve stimuli at interstimulus intervals of 5, 20, and 40. ms was measured. Anger expression, anxiety, and somatic concerns were investigated in migraine patients. Overall, SEP recovery cycle was shorter in migraineurs than in healthy controls. The recovery cycle of the frontal N30 SEP component was significantly shorter in IP than in EP patients. While among the EP patients those with faster N30 recovery cycle had higher Trait-Anger score, the opposite was found among the IP patients. Our results suggest that the inhibitory mechanisms within the somatosensory cortex are more impaired in IP than in EP migraine adolescents. The pathophysiological difference between IP and EP migraineurs was strengthened also by the opposite correlations between the brain excitability and the anger expression.
AB - Our aim was to investigate whether migraine adolescents with pain directed inside (imploding pain - IP) and outside (exploding pain - EP) the head may have different levels of cortical excitability underlying their migraineous syndrome. Ten migraine children referring prevalent EP (mean age 14.5. ±. 1.4 years, 3 girls, 7 boys), 10 patients with IP (mean age 14.1. ±. 2.2 years, 4 girls, 6 boys), and 13 control subjects (mean age 13. ±. 1.8 years, 6 males, 7 females) participated to the study. The recovery cycle of the somatosensory evoked potentials to electrical median nerve stimuli at interstimulus intervals of 5, 20, and 40. ms was measured. Anger expression, anxiety, and somatic concerns were investigated in migraine patients. Overall, SEP recovery cycle was shorter in migraineurs than in healthy controls. The recovery cycle of the frontal N30 SEP component was significantly shorter in IP than in EP patients. While among the EP patients those with faster N30 recovery cycle had higher Trait-Anger score, the opposite was found among the IP patients. Our results suggest that the inhibitory mechanisms within the somatosensory cortex are more impaired in IP than in EP migraine adolescents. The pathophysiological difference between IP and EP migraineurs was strengthened also by the opposite correlations between the brain excitability and the anger expression.
KW - Anger
KW - Exploding pain
KW - Imploding pain
KW - Migraine
KW - Somatosensory evoked potentials
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U2 - 10.1016/j.neures.2013.06.005
DO - 10.1016/j.neures.2013.06.005
M3 - Article
C2 - 23831516
AN - SCOPUS:84886388077
VL - 77
SP - 78
EP - 86
JO - Neuroscience Research
JF - Neuroscience Research
SN - 0168-0102
IS - 1-2
ER -