Different subcellular localization of ALCAM molecules in neuroblastoma: Association with relapse

Maria Valeria Corrias, Claudio Gambini, Andrea Gregorio, Michela Croce, Gaia Barisione, Claudia Cossu, Armando Rossello, Silvano Ferrini, Marina Fabbi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The Activated Leukocyte Cell Adhesion Molecule (ALCAM/CD166), involved in nervous system development, has been linked to tumor progression and metastasis in several tumors. No information is available on ALCAM expression in neuroblastoma, a childhood neoplasia originating from the sympathetic nervous system. Methods: ALCAM expression was analysed by immunofluorescence and immunohistochemistry on differentiated neuroblastoma cell lines and on archival specimens of stroma-poor, not MYCN amplified, resectable neuroblastoma tumors, respectively. Results: ALCAM is variously expressed in neuroblastoma cell lines, is shed by metalloproteases and is cleaved by ADAM17/TACE in vitro. ALCAM is expressed in neuroblastoma primary tumors with diverse patterns of subcellular localization and is highly expressed in the neuropil area in a subgroup of cases. Tumor specimens showing high expression of ALCAM at the membrane of the neuroblast body or low levels in the neuropil area are associated with relapse (P=0.044 and P

Original languageEnglish
Pages (from-to)77-86
Number of pages10
JournalCellular Oncology
Volume32
Issue number1-2
DOIs
Publication statusPublished - 2010

Keywords

  • ALCAM/CD166
  • Immunohistochemistry
  • Neuroblastoma
  • Prognosis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Molecular Medicine

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