Abstract
The porphyrogenic effect of chronic administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (25 μg/kg/week) to male C57BL/6 mice was evaluated through quantitative and qualitative analysis of the porphyrins accumulated and of porphyrinogen carboxylase activity in liver, kidney, spleen, brain and erythrocytes. The liver was the principal site of action, both for porphyrin accumulation and for enzyme inhibition, with kidney next, whereas brain and erythrocytes were unaffected. In the spleen, despite unchanged formation of total products of uroporphyrinogen III decarboxylation, both an increase and a decrease of coproporphyrinogen formation were observed, the decrease being concomitant with a higher accumulation of tissue porphyrins. When a reponse to TCDD was found, the formation of the products of decarboxylaction of uroporphyrinogen III were affected to different extents. The pattern of enzyme inhibition paralleled data reported in the literature regarding tissue distribution of TCDD and indicated that TCDD porphyria is a suitable experimental model for the human 'sporadic' type of porphyria cutanea tarda (PCT).
| Original language | English |
|---|---|
| Pages (from-to) | 201-210 |
| Number of pages | 10 |
| Journal | Toxicology Letters |
| Volume | 20 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1984 |
Fingerprint
Keywords
- 2,3,7,8-tetrachlorodibenzo-p-dioxin, porphyrins
- porphyria
- Porphyrinogen carboxylase
ASJC Scopus subject areas
- Toxicology
Cite this
Different susceptibility of mouse tissues to porphyrogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin. / Cantoni, L.; Dal Fiume, D.; Ferraroli, A.; Salmona, M.; Ruggieri, R.
In: Toxicology Letters, Vol. 20, No. 2, 1984, p. 201-210.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Different susceptibility of mouse tissues to porphyrogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin
AU - Cantoni, L.
AU - Dal Fiume, D.
AU - Ferraroli, A.
AU - Salmona, M.
AU - Ruggieri, R.
PY - 1984
Y1 - 1984
N2 - The porphyrogenic effect of chronic administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (25 μg/kg/week) to male C57BL/6 mice was evaluated through quantitative and qualitative analysis of the porphyrins accumulated and of porphyrinogen carboxylase activity in liver, kidney, spleen, brain and erythrocytes. The liver was the principal site of action, both for porphyrin accumulation and for enzyme inhibition, with kidney next, whereas brain and erythrocytes were unaffected. In the spleen, despite unchanged formation of total products of uroporphyrinogen III decarboxylation, both an increase and a decrease of coproporphyrinogen formation were observed, the decrease being concomitant with a higher accumulation of tissue porphyrins. When a reponse to TCDD was found, the formation of the products of decarboxylaction of uroporphyrinogen III were affected to different extents. The pattern of enzyme inhibition paralleled data reported in the literature regarding tissue distribution of TCDD and indicated that TCDD porphyria is a suitable experimental model for the human 'sporadic' type of porphyria cutanea tarda (PCT).
AB - The porphyrogenic effect of chronic administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (25 μg/kg/week) to male C57BL/6 mice was evaluated through quantitative and qualitative analysis of the porphyrins accumulated and of porphyrinogen carboxylase activity in liver, kidney, spleen, brain and erythrocytes. The liver was the principal site of action, both for porphyrin accumulation and for enzyme inhibition, with kidney next, whereas brain and erythrocytes were unaffected. In the spleen, despite unchanged formation of total products of uroporphyrinogen III decarboxylation, both an increase and a decrease of coproporphyrinogen formation were observed, the decrease being concomitant with a higher accumulation of tissue porphyrins. When a reponse to TCDD was found, the formation of the products of decarboxylaction of uroporphyrinogen III were affected to different extents. The pattern of enzyme inhibition paralleled data reported in the literature regarding tissue distribution of TCDD and indicated that TCDD porphyria is a suitable experimental model for the human 'sporadic' type of porphyria cutanea tarda (PCT).
KW - 2,3,7,8-tetrachlorodibenzo-p-dioxin, porphyrins
KW - porphyria
KW - Porphyrinogen carboxylase
UR - http://www.scopus.com/inward/record.url?scp=0021322670&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021322670&partnerID=8YFLogxK
U2 - 10.1016/0378-4274(84)90148-6
DO - 10.1016/0378-4274(84)90148-6
M3 - Article
C2 - 6695411
AN - SCOPUS:0021322670
VL - 20
SP - 201
EP - 210
JO - Toxicology Letters
JF - Toxicology Letters
SN - 0378-4274
IS - 2
ER -