Different susceptibility of mouse tissues to porphyrogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin

L. Cantoni, D. Dal Fiume, A. Ferraroli, M. Salmona, R. Ruggieri

Research output: Contribution to journalArticle

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Abstract

The porphyrogenic effect of chronic administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (25 μg/kg/week) to male C57BL/6 mice was evaluated through quantitative and qualitative analysis of the porphyrins accumulated and of porphyrinogen carboxylase activity in liver, kidney, spleen, brain and erythrocytes. The liver was the principal site of action, both for porphyrin accumulation and for enzyme inhibition, with kidney next, whereas brain and erythrocytes were unaffected. In the spleen, despite unchanged formation of total products of uroporphyrinogen III decarboxylation, both an increase and a decrease of coproporphyrinogen formation were observed, the decrease being concomitant with a higher accumulation of tissue porphyrins. When a reponse to TCDD was found, the formation of the products of decarboxylaction of uroporphyrinogen III were affected to different extents. The pattern of enzyme inhibition paralleled data reported in the literature regarding tissue distribution of TCDD and indicated that TCDD porphyria is a suitable experimental model for the human 'sporadic' type of porphyria cutanea tarda (PCT).

Original languageEnglish
Pages (from-to)201-210
Number of pages10
JournalToxicology Letters
Volume20
Issue number2
DOIs
Publication statusPublished - 1984

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Porphyrins
Uroporphyrinogens
Tissue
Enzyme inhibition
Liver
Porphyrinogens
Coproporphyrinogens
Brain
Spleen
Erythrocytes
Porphyria Cutanea Tarda
Kidney
Porphyrias
Decarboxylation
Tissue Distribution
Enzymes
Inbred C57BL Mouse
Theoretical Models
Polychlorinated Dibenzodioxins
1,4-dioxin

Keywords

  • 2,3,7,8-tetrachlorodibenzo-p-dioxin, porphyrins
  • porphyria
  • Porphyrinogen carboxylase

ASJC Scopus subject areas

  • Toxicology

Cite this

Different susceptibility of mouse tissues to porphyrogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin. / Cantoni, L.; Dal Fiume, D.; Ferraroli, A.; Salmona, M.; Ruggieri, R.

In: Toxicology Letters, Vol. 20, No. 2, 1984, p. 201-210.

Research output: Contribution to journalArticle

Cantoni, L. ; Dal Fiume, D. ; Ferraroli, A. ; Salmona, M. ; Ruggieri, R. / Different susceptibility of mouse tissues to porphyrogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin. In: Toxicology Letters. 1984 ; Vol. 20, No. 2. pp. 201-210.
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