Different susceptibility to the development of nitroglycerin tolerance in the arterial and venous circulation in humans: Effects of N-acetylcysteine administration

Stefano Ghio, Stefano De Servi, Rubens Perotti, Ermanno Eleuteri, Carlo Montemartini, Giuseppe Specchia

Research output: Contribution to journalArticle

Abstract

Background. Tolerance to the effects of organic nitrates develops rapidly during continuous exposure to these drugs; its main mechanism seems to be an intracellular sulfhydryl group depletion. However, the relative susceptibility to the development of nitroglycerin tolerance of the arterial or venous circulation in humans is still a matter of dispute. Methods and Results. Twenty patients with coronary artery disease underwent a continuous 24-hour nitroglycerin infusion followed by a bolus administration of N-acetylcysteine. Forearm blood flow (ml/100 ml/min) and venous volume (ml/100 ml) were measured by strain gauge plethysmography under control conditions, at the end of nitroglycerin titration, after 24-hour infusion, and after N-acetylcysteine; vascular resistance was calculated as mean cuff blood pressure divided by flow. After 24 hours of nitroglycerin infusion, the initial increase in venous volume was reduced 48% (p

Original languageEnglish
Pages (from-to)798-802
Number of pages5
JournalCirculation
Volume86
Issue number3
Publication statusPublished - Sep 1992

Keywords

  • N-acetylcysteine
  • Nitrate tolerance
  • Plethysmography

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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