Different thallium-201 single-photon emission tomographic patterns in benign and aggressive meningiomas

Enrico Tedeschi, Andrea Soricelli, Arturo Brunetti, Maurizio Romano, Alfredo Bucciero, Giorgio Iaconetta, Alessandra Alfieri, Alfredo Postiglione, Marco Salvatore

Research output: Contribution to journalArticle

Abstract

To evaluate the possibility of preoperatively obtaining an index of aggressiveness for intracranial meningiomas, we prospectively studied 22 patients with computed tomographic or magnetic resonance imaging evidence of meningeal tumour, using single-photon emission tomography (SPET) of the brain and thallium-201 (201T1). On a brain-dedicated SPET scanner, a rapid acquisition protocol with early, short scans was started simultaneously with the intravenous administration of 111 NIBq 201T1, covering the initial intratumoral distribution of the tracer. Twenty minutes post injection, a delayed SPET scan was also obtained. On the reconstructed and attenuation-corrected images we calculated the 201T1 concentration in tumour and normal contralateral brain tissue, and compared intratumoral tracer concentration in the initial and the final part of the rapid acquisition protocol. Benign and malignant meningiomas were classified as such based on histological examination. In malignant lesions, the ratio of the 201T1 concentration at 2-4 min post injection to that at 14-16 min was found to be significantly higher than in non-aggressive neoplasms (mean±1 SD: 1.14±0.31 and 0.56±0.13, respectively, P 201T1 concentration values at 2-3 and at 14-16 min. Our findings suggest that the comparative assessment of intratumoral 201T1 concentration at 2-4 and at 14-16 min post injection could provide a fast, simple method to differentiate preoperatively intracranial meningiomas with different biological behaviour.

Original languageEnglish
Pages (from-to)1478-1484
Number of pages7
JournalEuropean Journal Of Nuclear Medicine
Volume23
Issue number11
DOIs
Publication statusPublished - 1996

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Keywords

  • Meningioma
  • Single-photon emission tomography
  • Thallium-201 imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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