TY - JOUR
T1 - Different thallium-201 single-photon emission tomographic patterns in benign and aggressive meningiomas
AU - Tedeschi, Enrico
AU - Soricelli, Andrea
AU - Brunetti, Arturo
AU - Romano, Maurizio
AU - Bucciero, Alfredo
AU - Iaconetta, Giorgio
AU - Alfieri, Alessandra
AU - Postiglione, Alfredo
AU - Salvatore, Marco
PY - 1996
Y1 - 1996
N2 - To evaluate the possibility of preoperatively obtaining an index of aggressiveness for intracranial meningiomas, we prospectively studied 22 patients with computed tomographic or magnetic resonance imaging evidence of meningeal tumour, using single-photon emission tomography (SPET) of the brain and thallium-201 (201T1). On a brain-dedicated SPET scanner, a rapid acquisition protocol with early, short scans was started simultaneously with the intravenous administration of 111 NIBq 201T1, covering the initial intratumoral distribution of the tracer. Twenty minutes post injection, a delayed SPET scan was also obtained. On the reconstructed and attenuation-corrected images we calculated the 201T1 concentration in tumour and normal contralateral brain tissue, and compared intratumoral tracer concentration in the initial and the final part of the rapid acquisition protocol. Benign and malignant meningiomas were classified as such based on histological examination. In malignant lesions, the ratio of the 201T1 concentration at 2-4 min post injection to that at 14-16 min was found to be significantly higher than in non-aggressive neoplasms (mean±1 SD: 1.14±0.31 and 0.56±0.13, respectively, P 201T1 concentration values at 2-3 and at 14-16 min. Our findings suggest that the comparative assessment of intratumoral 201T1 concentration at 2-4 and at 14-16 min post injection could provide a fast, simple method to differentiate preoperatively intracranial meningiomas with different biological behaviour.
AB - To evaluate the possibility of preoperatively obtaining an index of aggressiveness for intracranial meningiomas, we prospectively studied 22 patients with computed tomographic or magnetic resonance imaging evidence of meningeal tumour, using single-photon emission tomography (SPET) of the brain and thallium-201 (201T1). On a brain-dedicated SPET scanner, a rapid acquisition protocol with early, short scans was started simultaneously with the intravenous administration of 111 NIBq 201T1, covering the initial intratumoral distribution of the tracer. Twenty minutes post injection, a delayed SPET scan was also obtained. On the reconstructed and attenuation-corrected images we calculated the 201T1 concentration in tumour and normal contralateral brain tissue, and compared intratumoral tracer concentration in the initial and the final part of the rapid acquisition protocol. Benign and malignant meningiomas were classified as such based on histological examination. In malignant lesions, the ratio of the 201T1 concentration at 2-4 min post injection to that at 14-16 min was found to be significantly higher than in non-aggressive neoplasms (mean±1 SD: 1.14±0.31 and 0.56±0.13, respectively, P 201T1 concentration values at 2-3 and at 14-16 min. Our findings suggest that the comparative assessment of intratumoral 201T1 concentration at 2-4 and at 14-16 min post injection could provide a fast, simple method to differentiate preoperatively intracranial meningiomas with different biological behaviour.
KW - Meningioma
KW - Single-photon emission tomography
KW - Thallium-201 imaging
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U2 - 10.1007/BF01254472
DO - 10.1007/BF01254472
M3 - Article
C2 - 8854846
AN - SCOPUS:0029862214
VL - 23
SP - 1478
EP - 1484
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
SN - 0340-6199
IS - 11
ER -