Different types of cell death in organismal aging and longevity: State of the art and possible systems biology approach

Stefano Salvioli; Miriam Capri; Paolo Tieri; Jonathan Loroni; Cristiana Barbi; Laura Invidia; Serena Altilia; Aurelia Santoro; Chiara Pirazzini; Michela Pierini; Elena Bellavista; Lilia Alberghina; Claudio Franceschi

doi:10.2174/138161208783413266

Different types of cell death in organismal aging and longevity: State of the art and possible systems biology approach

Stefano Salvioli, Miriam Capri, Paolo Tieri, Jonathan Loroni, Cristiana Barbi, Laura Invidia, Serena Altilia, Aurelia Santoro, Chiara Pirazzini, Michela Pierini, Elena Bellavista, Lilia Alberghina, Claudio Franceschi

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article › peer-review

Abstract

Cell death is as important as cell proliferation for cell turn-over, and susceptibility to cell death is affected by a number of parameters that change with time. A time-dependent derangement of such a crucial process, or even the simple cell loss mediated by cell death impinges upon aging and longevity. In this review we will discuss how cell death phenomena are modulated during aging and what is their possible role in the aging process. We will focus on apoptosis and autophagy, which affect mostly proliferating and post-mitotic cells, respectively, and on mitochondrial degradation in long living cells. Since the "decisional process" that leads the cell to death is very complex, we will also discuss the possibility to address this topic with a systems biology approach.

Original language	English
Pages (from-to)	226-236
Number of pages	11
Journal	Current Pharmaceutical Design
Volume	14
Issue number	3
DOIs	https://doi.org/10.2174/138161208783413266
Publication status	Published - Jan 2008

ASJC Scopus subject areas

Molecular Medicine
Pharmacology, Toxicology and Pharmaceutics(all)

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10.2174/138161208783413266

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Salvioli, S., Capri, M., Tieri, P., Loroni, J., Barbi, C., Invidia, L., Altilia, S., Santoro, A., Pirazzini, C., Pierini, M., Bellavista, E., Alberghina, L., & Franceschi, C. (2008). Different types of cell death in organismal aging and longevity: State of the art and possible systems biology approach. Current Pharmaceutical Design, 14(3), 226-236. https://doi.org/10.2174/138161208783413266

Different types of cell death in organismal aging and longevity : State of the art and possible systems biology approach. / Salvioli, Stefano; Capri, Miriam; Tieri, Paolo; Loroni, Jonathan; Barbi, Cristiana; Invidia, Laura; Altilia, Serena; Santoro, Aurelia; Pirazzini, Chiara; Pierini, Michela; Bellavista, Elena; Alberghina, Lilia; Franceschi, Claudio.

In: Current Pharmaceutical Design, Vol. 14, No. 3, 01.2008, p. 226-236.

Research output: Contribution to journal › Article › peer-review

Salvioli, S, Capri, M, Tieri, P, Loroni, J, Barbi, C, Invidia, L, Altilia, S, Santoro, A, Pirazzini, C, Pierini, M, Bellavista, E, Alberghina, L & Franceschi, C 2008, 'Different types of cell death in organismal aging and longevity: State of the art and possible systems biology approach', Current Pharmaceutical Design, vol. 14, no. 3, pp. 226-236. https://doi.org/10.2174/138161208783413266

Salvioli, Stefano ; Capri, Miriam ; Tieri, Paolo ; Loroni, Jonathan ; Barbi, Cristiana ; Invidia, Laura ; Altilia, Serena ; Santoro, Aurelia ; Pirazzini, Chiara ; Pierini, Michela ; Bellavista, Elena ; Alberghina, Lilia ; Franceschi, Claudio. / Different types of cell death in organismal aging and longevity : State of the art and possible systems biology approach. In: Current Pharmaceutical Design. 2008 ; Vol. 14, No. 3. pp. 226-236.

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AU - Santoro, Aurelia

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Different types of cell death in organismal aging and longevity: State of the art and possible systems biology approach

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