TY - JOUR
T1 - Different types of cell death in organismal aging and longevity
T2 - State of the art and possible systems biology approach
AU - Salvioli, Stefano
AU - Capri, Miriam
AU - Tieri, Paolo
AU - Loroni, Jonathan
AU - Barbi, Cristiana
AU - Invidia, Laura
AU - Altilia, Serena
AU - Santoro, Aurelia
AU - Pirazzini, Chiara
AU - Pierini, Michela
AU - Bellavista, Elena
AU - Alberghina, Lilia
AU - Franceschi, Claudio
PY - 2008/1
Y1 - 2008/1
N2 - Cell death is as important as cell proliferation for cell turn-over, and susceptibility to cell death is affected by a number of parameters that change with time. A time-dependent derangement of such a crucial process, or even the simple cell loss mediated by cell death impinges upon aging and longevity. In this review we will discuss how cell death phenomena are modulated during aging and what is their possible role in the aging process. We will focus on apoptosis and autophagy, which affect mostly proliferating and post-mitotic cells, respectively, and on mitochondrial degradation in long living cells. Since the "decisional process" that leads the cell to death is very complex, we will also discuss the possibility to address this topic with a systems biology approach.
AB - Cell death is as important as cell proliferation for cell turn-over, and susceptibility to cell death is affected by a number of parameters that change with time. A time-dependent derangement of such a crucial process, or even the simple cell loss mediated by cell death impinges upon aging and longevity. In this review we will discuss how cell death phenomena are modulated during aging and what is their possible role in the aging process. We will focus on apoptosis and autophagy, which affect mostly proliferating and post-mitotic cells, respectively, and on mitochondrial degradation in long living cells. Since the "decisional process" that leads the cell to death is very complex, we will also discuss the possibility to address this topic with a systems biology approach.
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U2 - 10.2174/138161208783413266
DO - 10.2174/138161208783413266
M3 - Article
C2 - 18220833
AN - SCOPUS:39749152243
VL - 14
SP - 226
EP - 236
JO - Current Pharmaceutical Design
JF - Current Pharmaceutical Design
SN - 1381-6128
IS - 3
ER -