Abstract
Background - Reappearance of low-frequency (LF) (±0.10 Hz) oscillations in RR interval (RR) after cardiac transplantation is indicative of sympathetic efferent reinnervation. We hypothesized that restored LF oscillations in RR in heart transplant recipients (HTRs) are linked to oscillations in muscle sympathetic nerve traffic (MSNA). Methods and Results - RR, RR variability, and MSNA were recorded 5±2 months (n=7, short-term HTRs) and 138±8 months (n=7, long-term HTRs) after heart transplantation and compared with matched hypertensive patients (n=7). A coherence function determined the coupling between LF oscillations in MSNA and RR. RR variance did not differ between short-term and long-term HTRs. However, LF variability was only 1±0.5 ms2 in the short-term HTRs but was 15±8 ms2 in the long-term HTRs (P
Original language | English |
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Pages (from-to) | 1809-1813 |
Number of pages | 5 |
Journal | Circulation |
Volume | 104 |
Issue number | 15 |
Publication status | Published - Oct 9 2001 |
Keywords
- Circulation
- Nervous system, sympathetic
- Transplantation
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine