Differential characteristics of neural circulatory control: Early versus late after cardiac transplantation

Philippe Van De Borne, Jolanta Neubauer, Mohsen Rahnama, Jean Luc Jansens, Nicola Montano, Alberto Porta, Virend K. Somers, Jean Paul Degaute

Research output: Contribution to journalArticlepeer-review

Abstract

Background - Reappearance of low-frequency (LF) (±0.10 Hz) oscillations in RR interval (RR) after cardiac transplantation is indicative of sympathetic efferent reinnervation. We hypothesized that restored LF oscillations in RR in heart transplant recipients (HTRs) are linked to oscillations in muscle sympathetic nerve traffic (MSNA). Methods and Results - RR, RR variability, and MSNA were recorded 5±2 months (n=7, short-term HTRs) and 138±8 months (n=7, long-term HTRs) after heart transplantation and compared with matched hypertensive patients (n=7). A coherence function determined the coupling between LF oscillations in MSNA and RR. RR variance did not differ between short-term and long-term HTRs. However, LF variability was only 1±0.5 ms2 in the short-term HTRs but was 15±8 ms2 in the long-term HTRs (P

Original languageEnglish
Pages (from-to)1809-1813
Number of pages5
JournalCirculation
Volume104
Issue number15
Publication statusPublished - Oct 9 2001

Keywords

  • Circulation
  • Nervous system, sympathetic
  • Transplantation

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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