Differential characteristics of neural circulatory control: Early versus late after cardiac transplantation

Philippe Van De Borne; Jolanta Neubauer; Mohsen Rahnama; Jean Luc Jansens; Nicola Montano; Alberto Porta; Virend K. Somers; Jean Paul Degaute

Differential characteristics of neural circulatory control: Early versus late after cardiac transplantation

Philippe Van De Borne, Jolanta Neubauer, Mohsen Rahnama, Jean Luc Jansens, Nicola Montano, Alberto Porta, Virend K. Somers, Jean Paul Degaute

Research output: Contribution to journal › Article › peer-review

Abstract

Background - Reappearance of low-frequency (LF) (±0.10 Hz) oscillations in RR interval (RR) after cardiac transplantation is indicative of sympathetic efferent reinnervation. We hypothesized that restored LF oscillations in RR in heart transplant recipients (HTRs) are linked to oscillations in muscle sympathetic nerve traffic (MSNA). Methods and Results - RR, RR variability, and MSNA were recorded 5±2 months (n=7, short-term HTRs) and 138±8 months (n=7, long-term HTRs) after heart transplantation and compared with matched hypertensive patients (n=7). A coherence function determined the coupling between LF oscillations in MSNA and RR. RR variance did not differ between short-term and long-term HTRs. However, LF variability was only 1±0.5 ms² in the short-term HTRs but was 15±8 ms² in the long-term HTRs (P

Original language	English
Pages (from-to)	1809-1813
Number of pages	5
Journal	Circulation
Volume	104
Issue number	15
Publication status	Published - Oct 9 2001

Keywords

Circulation
Nervous system, sympathetic
Transplantation

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

Cite this

@article{904802c8f86c401a8751045fe12bb40e,

title = "Differential characteristics of neural circulatory control: Early versus late after cardiac transplantation",

abstract = "Background - Reappearance of low-frequency (LF) (±0.10 Hz) oscillations in RR interval (RR) after cardiac transplantation is indicative of sympathetic efferent reinnervation. We hypothesized that restored LF oscillations in RR in heart transplant recipients (HTRs) are linked to oscillations in muscle sympathetic nerve traffic (MSNA). Methods and Results - RR, RR variability, and MSNA were recorded 5±2 months (n=7, short-term HTRs) and 138±8 months (n=7, long-term HTRs) after heart transplantation and compared with matched hypertensive patients (n=7). A coherence function determined the coupling between LF oscillations in MSNA and RR. RR variance did not differ between short-term and long-term HTRs. However, LF variability was only 1±0.5 ms2 in the short-term HTRs but was 15±8 ms2 in the long-term HTRs (P",

keywords = "Circulation, Nervous system, sympathetic, Transplantation",

author = "{Van De Borne}, Philippe and Jolanta Neubauer and Mohsen Rahnama and Jansens, {Jean Luc} and Nicola Montano and Alberto Porta and Somers, {Virend K.} and Degaute, {Jean Paul}",

year = "2001",

month = oct,

day = "9",

language = "English",

volume = "104",

pages = "1809--1813",

journal = "Circulation",

issn = "0009-7322",

publisher = "Lippincott Williams and Wilkins",

number = "15",

}

TY - JOUR

T1 - Differential characteristics of neural circulatory control

T2 - Early versus late after cardiac transplantation

AU - Van De Borne, Philippe

AU - Neubauer, Jolanta

AU - Rahnama, Mohsen

AU - Jansens, Jean Luc

AU - Montano, Nicola

AU - Porta, Alberto

AU - Somers, Virend K.

AU - Degaute, Jean Paul

PY - 2001/10/9

Y1 - 2001/10/9

N2 - Background - Reappearance of low-frequency (LF) (±0.10 Hz) oscillations in RR interval (RR) after cardiac transplantation is indicative of sympathetic efferent reinnervation. We hypothesized that restored LF oscillations in RR in heart transplant recipients (HTRs) are linked to oscillations in muscle sympathetic nerve traffic (MSNA). Methods and Results - RR, RR variability, and MSNA were recorded 5±2 months (n=7, short-term HTRs) and 138±8 months (n=7, long-term HTRs) after heart transplantation and compared with matched hypertensive patients (n=7). A coherence function determined the coupling between LF oscillations in MSNA and RR. RR variance did not differ between short-term and long-term HTRs. However, LF variability was only 1±0.5 ms2 in the short-term HTRs but was 15±8 ms2 in the long-term HTRs (P

AB - Background - Reappearance of low-frequency (LF) (±0.10 Hz) oscillations in RR interval (RR) after cardiac transplantation is indicative of sympathetic efferent reinnervation. We hypothesized that restored LF oscillations in RR in heart transplant recipients (HTRs) are linked to oscillations in muscle sympathetic nerve traffic (MSNA). Methods and Results - RR, RR variability, and MSNA were recorded 5±2 months (n=7, short-term HTRs) and 138±8 months (n=7, long-term HTRs) after heart transplantation and compared with matched hypertensive patients (n=7). A coherence function determined the coupling between LF oscillations in MSNA and RR. RR variance did not differ between short-term and long-term HTRs. However, LF variability was only 1±0.5 ms2 in the short-term HTRs but was 15±8 ms2 in the long-term HTRs (P

KW - Circulation

KW - Nervous system, sympathetic

KW - Transplantation

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M3 - Article

C2 - 11591619

AN - SCOPUS:0035834085

VL - 104

SP - 1809

EP - 1813

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 15

ER -

Differential characteristics of neural circulatory control: Early versus late after cardiac transplantation

Abstract

Keywords

ASJC Scopus subject areas

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