TY - JOUR
T1 - Differential Decrease of Copper Content and of Copper Binding to Superoxide Dismutase in Liver, Heart and Brain of Copper-Deficient Rats
AU - Rossi, L.
AU - Ciriolo, M. R.
AU - Marchese, E.
AU - Demartino, A.
AU - Giorgi, M.
AU - Rotilio, G.
PY - 1994/9/15
Y1 - 1994/9/15
N2 - Dietary copper-deficiency in rats produced a organ-specific decrease of copper content. This was paralleled by a decrease of the activity of the copper-enzyme superoxide dismutase. In liver such a decrease is partially due to the existence of an ape-form of superoxide dismutase, which can be reactivated by addition of exogenous copper to tissue extracts. These results demonstrate in vivo that superoxide dismutase is post-translationally modulated by copper in higher vertebrates as previously found for yeast and mammalian cells in culture.
AB - Dietary copper-deficiency in rats produced a organ-specific decrease of copper content. This was paralleled by a decrease of the activity of the copper-enzyme superoxide dismutase. In liver such a decrease is partially due to the existence of an ape-form of superoxide dismutase, which can be reactivated by addition of exogenous copper to tissue extracts. These results demonstrate in vivo that superoxide dismutase is post-translationally modulated by copper in higher vertebrates as previously found for yeast and mammalian cells in culture.
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U2 - 10.1006/bbrc.1994.2285
DO - 10.1006/bbrc.1994.2285
M3 - Article
C2 - 8093020
AN - SCOPUS:0028106354
VL - 203
SP - 1028
EP - 1034
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 2
ER -