Differential Decrease of Copper Content and of Copper Binding to Superoxide Dismutase in Liver, Heart and Brain of Copper-Deficient Rats

L. Rossi, M. R. Ciriolo, E. Marchese, A. Demartino, M. Giorgi, G. Rotilio

Research output: Contribution to journalArticlepeer-review

Abstract

Dietary copper-deficiency in rats produced a organ-specific decrease of copper content. This was paralleled by a decrease of the activity of the copper-enzyme superoxide dismutase. In liver such a decrease is partially due to the existence of an ape-form of superoxide dismutase, which can be reactivated by addition of exogenous copper to tissue extracts. These results demonstrate in vivo that superoxide dismutase is post-translationally modulated by copper in higher vertebrates as previously found for yeast and mammalian cells in culture.

Original languageEnglish
Pages (from-to)1028-1034
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume203
Issue number2
DOIs
Publication statusPublished - Sep 15 1994

ASJC Scopus subject areas

  • Molecular Biology
  • Biophysics
  • Biochemistry

Fingerprint Dive into the research topics of 'Differential Decrease of Copper Content and of Copper Binding to Superoxide Dismutase in Liver, Heart and Brain of Copper-Deficient Rats'. Together they form a unique fingerprint.

Cite this