Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease

INSIGHT-preAD study group, Alzheimer Precision Medicine Initiative (APMI)

Research output: Contribution to journalArticle

Abstract

Introduction: The longitudinal trajectories of functional brain dynamics and the impact of genetic risk factors in individuals at risk for Alzheimer's disease are poorly understood. Methods: In a large-scale monocentric cohort of 224 amyloid stratified individuals at risk for Alzheimer's disease, default mode network (DMN) resting state functional connectivity (FC) was investigated between two serial time points across 2 years. Results: Widespread DMN FC changes were shown in frontal and posterior areas, as well as in the right hippocampus. There were no cross-sectional differences, however, apolipoprotein E ε4 (APOE ε4) carriers demonstrated slower increase in FC in frontal lobes. There was no impact of individual brain amyloid load status. Discussion: For the first time, we demonstrated that the pleiotropic biological effect of the APOE ε4 allele impacts the dynamic trajectory of the DMN during aging. Dynamic functional biomarkers may become useful surrogate outcomes for the development of preclinical targeted therapeutic interventions.

Original languageEnglish
Pages (from-to)940-950
Number of pages11
JournalAlzheimer's and Dementia
Volume15
Issue number7
DOIs
Publication statusPublished - Jul 1 2019

Fingerprint

Apolipoprotein E4
Amyloid
Alzheimer Disease
Brain
Frontal Lobe
Hippocampus
Biomarkers
Alleles
Therapeutics

Keywords

  • Alzheimer's disease
  • Brain functional dynamics
  • fMRI
  • Precision medicine
  • Subjective memory complaints

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

Cite this

Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease. / INSIGHT-preAD study group; Alzheimer Precision Medicine Initiative (APMI).

In: Alzheimer's and Dementia, Vol. 15, No. 7, 01.07.2019, p. 940-950.

Research output: Contribution to journalArticle

INSIGHT-preAD study group & Alzheimer Precision Medicine Initiative (APMI) 2019, 'Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease', Alzheimer's and Dementia, vol. 15, no. 7, pp. 940-950. https://doi.org/10.1016/j.jalz.2019.03.006
INSIGHT-preAD study group ; Alzheimer Precision Medicine Initiative (APMI). / Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease. In: Alzheimer's and Dementia. 2019 ; Vol. 15, No. 7. pp. 940-950.
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AU - Lista, Simone

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AU - Dubois, Bruno

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AU - Bertin, Hugo

AU - Bonheur, Joel

AU - Boukadida, Laurie

AU - Boukerrou, Nadia

AU - Chiesa, Patrizia

AU - Colliot, Olivier

AU - Dubois, Marion

AU - Epelbaum, Stéphane

AU - Gagliardi, Geoffroy

AU - Genthon, Remy

AU - Houot, Marion

AU - Kas, Aurélie

AU - Lamari, Foudil

AU - Levy, Marcel

AU - Metzinger, Christiane

AU - Mochel, Fanny

AU - Nyasse, Francis

AU - Poisson, Catherine

AU - Revillon, Marie

AU - Santos, Antonio

AU - Andrade, Katia Santos

AU - Sole, Marine

AU - Surtee, Mohmed

AU - de Schotten, Michel Thiebaud

AU - Younsi, Nadjia

AU - Afshar, Mohammad

AU - Aguilar, Lisi Flores

AU - Akman-Anderson, Leyla

AU - Arenas, Joaquín

AU - Avila, Jesus

AU - Babiloni, Claudio

AU - Baldacci, Filippo

AU - Batrla, Richard

AU - Benda, Norbert

AU - Black, Keith L.

AU - Bokde, Arun L.W.

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