Differential development of type 1 and type 2 cytokines and β-chemokines in the ontogeny of healthy newborns

Alessandra Vigano, Susanna Esposito, Donatella Arienti, Arianna Zagliani, Emilia Massironi, Nicola Principi, Mario Clerici

Research output: Contribution to journalArticle

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Abstract

Interleukin (IL)-2, interferon gamma (IFN-γ; type 1 cytokines), IL-4, and IL-10 (type 2 cytokines), and β-chemokines (MIP-1α and RANTES) production by cord blood lymphocytes (CBL) and peripheral blood lymphocytes (PBL) of newborns was analyzed in a cross-sectional study to examine the maturation of these components of the immune response. Immunophenotyping was performed on the same specimens. Results showed that the CD4/CD8 ratio remains stable, the percentage of natural killer cells decreases, and the number and percentage of B cells increase after birth. Analysis of cytokine production suggested that the production of all cytokines increases gradually and steadily after birth, and that IFN-γ and IL-10 production is reduced at birth whereas IL-2 and IL-4 production is not. Finally, mitogen-stimulated β-chemokine production was present at birth and increased slightly but significantly with age. These data indicate that a differential functional maturation of immune response after birth favoring a more precocious development of IL-2 (a type 1 cytokine) is present and should help to analyze the ontogeny of the immune system.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalBiology of the Neonate
Volume75
Issue number1
DOIs
Publication statusPublished - 1999

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Chemokines
Parturition
Interleukin-2
Cytokines
Interleukin-4
Interleukin-10
Lymphocytes
Immunophenotyping
Chemokine CCL5
CD4-CD8 Ratio
Fetal Blood
Mitogens
Natural Killer Cells
Interferon-gamma
Immune System
B-Lymphocytes
Cell Count
Cross-Sectional Studies

Keywords

  • β-chemokines
  • Cytokines
  • Immunity
  • Infant
  • Newborn
  • Ontogeny

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

Cite this

Differential development of type 1 and type 2 cytokines and β-chemokines in the ontogeny of healthy newborns. / Vigano, Alessandra; Esposito, Susanna; Arienti, Donatella; Zagliani, Arianna; Massironi, Emilia; Principi, Nicola; Clerici, Mario.

In: Biology of the Neonate, Vol. 75, No. 1, 1999, p. 1-8.

Research output: Contribution to journalArticle

Vigano, Alessandra ; Esposito, Susanna ; Arienti, Donatella ; Zagliani, Arianna ; Massironi, Emilia ; Principi, Nicola ; Clerici, Mario. / Differential development of type 1 and type 2 cytokines and β-chemokines in the ontogeny of healthy newborns. In: Biology of the Neonate. 1999 ; Vol. 75, No. 1. pp. 1-8.
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