Differential diagnosis of lipoma-like lipoblastoma

Cristina Morerio, Paolo Nozza, Elisa Tassano, Cristina Rosanda, Claudio Granata, Massimo Conte, Claudio Panarello

Research output: Contribution to journalArticle

Abstract

Lipoblastomas are rare benign tumors of white fatty tissue that occur primarily in young children. Occasionally, heterogeneity of morphological appearance and histological overlap with other lipogenic tumors are described. In such cases fluorescence in situ hybridization (FISH) analysis of PLAG1, a gene specifically rearranged in lipoblastoma, is necessary to prevent misdiagnosis. We present a case of lipoblastoma arising in an atypical site with histological features characteristic of lipoma. The correct diagnosis was made possible on cytogenetic grounds through the identification of the characteristic PLAG1-HAS2 fusion gene, thus allowing an appropriate clinical approach.

Original languageEnglish
Pages (from-to)132-134
Number of pages3
JournalPediatric Blood and Cancer
Volume52
Issue number1
DOIs
Publication statusPublished - Jan 2009

Keywords

  • FISH
  • Lipoblastoma
  • Lipoma
  • PLAG1-HAS2 fusion gene

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Medicine(all)

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