Abstract
Interleukin-2 (IL-2) increases circulating CD4+ lymphocytes in patients infected with human immunodeficiency virus-1. We studied Epstein-Barr virus (EBV) dynamics in 40 patients treated with antiretroviral therapy (ART) plus different IL-2 regimens. EBV-DNA tended to increase in both peripheral blood cells and plasma after continous infusion followed by intermittent subcutaneous high-dose IL-2, while EBV-DNA decreased in cells (p=0.0078) and disappeared in plasma after intermittent subcutaneous low-dose IL-2. Over 12 months, the dynamics of EBV differed between the two groups both in cells (p=0.0184) and plasma (p=0.0114). Thus, as a function of dose, IL-2 therapy may significantly affect the dynamics of EBV infection.
Original language | English |
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Pages (from-to) | 244-247 |
Number of pages | 4 |
Journal | Haematologica |
Volume | 91 |
Issue number | 2 |
Publication status | Published - Feb 2006 |
Keywords
- ART
- EBV
- HIV-1
- IL-2
ASJC Scopus subject areas
- Hematology