Differential dynamics of Epstein-Barr virus in individuals infected with human immunodeficiency virus-1 receiving intermittent interleukin-2 and antiretroviral therapy

Nicoletta Burighel; Silvia Ghezzi; Silvia Nozza; Paola Del Bianco; Adriano Lazzarin; Giuseppe Tambussi; Guido Poli; Anita De Rossi

Differential dynamics of Epstein-Barr virus in individuals infected with human immunodeficiency virus-1 receiving intermittent interleukin-2 and antiretroviral therapy

Nicoletta Burighel, Silvia Ghezzi, Silvia Nozza, Paola Del Bianco, Adriano Lazzarin, Giuseppe Tambussi, Guido Poli, Anita De Rossi

Research output: Contribution to journal › Article › peer-review

Abstract

Interleukin-2 (IL-2) increases circulating CD4⁺ lymphocytes in patients infected with human immunodeficiency virus-1. We studied Epstein-Barr virus (EBV) dynamics in 40 patients treated with antiretroviral therapy (ART) plus different IL-2 regimens. EBV-DNA tended to increase in both peripheral blood cells and plasma after continous infusion followed by intermittent subcutaneous high-dose IL-2, while EBV-DNA decreased in cells (p=0.0078) and disappeared in plasma after intermittent subcutaneous low-dose IL-2. Over 12 months, the dynamics of EBV differed between the two groups both in cells (p=0.0184) and plasma (p=0.0114). Thus, as a function of dose, IL-2 therapy may significantly affect the dynamics of EBV infection.

Original language	English
Pages (from-to)	244-247
Number of pages	4
Journal	Haematologica
Volume	91
Issue number	2
Publication status	Published - Feb 2006

Keywords

ART
EBV
HIV-1
IL-2

ASJC Scopus subject areas

Hematology

Cite this

Differential dynamics of Epstein-Barr virus in individuals infected with human immunodeficiency virus-1 receiving intermittent interleukin-2 and antiretroviral therapy. / Burighel, Nicoletta; Ghezzi, Silvia; Nozza, Silvia ; Del Bianco, Paola; Lazzarin, Adriano; Tambussi, Giuseppe; Poli, Guido ; De Rossi, Anita.

In: Haematologica, Vol. 91, No. 2, 02.2006, p. 244-247.

Research output: Contribution to journal › Article › peer-review

Burighel, Nicoletta ; Ghezzi, Silvia ; Nozza, Silvia ; Del Bianco, Paola ; Lazzarin, Adriano ; Tambussi, Giuseppe ; Poli, Guido ; De Rossi, Anita. / Differential dynamics of Epstein-Barr virus in individuals infected with human immunodeficiency virus-1 receiving intermittent interleukin-2 and antiretroviral therapy. In: Haematologica. 2006 ; Vol. 91, No. 2. pp. 244-247.

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abstract = "Interleukin-2 (IL-2) increases circulating CD4+ lymphocytes in patients infected with human immunodeficiency virus-1. We studied Epstein-Barr virus (EBV) dynamics in 40 patients treated with antiretroviral therapy (ART) plus different IL-2 regimens. EBV-DNA tended to increase in both peripheral blood cells and plasma after continous infusion followed by intermittent subcutaneous high-dose IL-2, while EBV-DNA decreased in cells (p=0.0078) and disappeared in plasma after intermittent subcutaneous low-dose IL-2. Over 12 months, the dynamics of EBV differed between the two groups both in cells (p=0.0184) and plasma (p=0.0114). Thus, as a function of dose, IL-2 therapy may significantly affect the dynamics of EBV infection.",

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AU - Burighel, Nicoletta

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AU - Del Bianco, Paola

AU - Lazzarin, Adriano

AU - Tambussi, Giuseppe

AU - Poli, Guido

AU - De Rossi, Anita

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AB - Interleukin-2 (IL-2) increases circulating CD4+ lymphocytes in patients infected with human immunodeficiency virus-1. We studied Epstein-Barr virus (EBV) dynamics in 40 patients treated with antiretroviral therapy (ART) plus different IL-2 regimens. EBV-DNA tended to increase in both peripheral blood cells and plasma after continous infusion followed by intermittent subcutaneous high-dose IL-2, while EBV-DNA decreased in cells (p=0.0078) and disappeared in plasma after intermittent subcutaneous low-dose IL-2. Over 12 months, the dynamics of EBV differed between the two groups both in cells (p=0.0184) and plasma (p=0.0114). Thus, as a function of dose, IL-2 therapy may significantly affect the dynamics of EBV infection.

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Differential dynamics of Epstein-Barr virus in individuals infected with human immunodeficiency virus-1 receiving intermittent interleukin-2 and antiretroviral therapy

Abstract

Keywords

ASJC Scopus subject areas

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