Differential effect of acute reserpine administration on D-1 and D-2 dopaminergic receptor density and function in rat striatum

Paolo Liberini, Enzo Nisoli, Cristina Missale, Maurizio Memo, Matilde Buonamici, Alessandro Rossi, Pier Franco Spano

Research output: Contribution to journalArticlepeer-review

Abstract

In the present study we investigated the effects of a single injection of reserpine on dopamine receptor function in rat striatum. The measurement of adenylate cyclase activity indicated that cAMP formation induced by the selective D-1 agonist SKF 82526 was greatly increased 2 and 20 h after reserpine; in contrast, the selective D-2 agonist bromocriptine inhibited by the same extent and with the same potency AC in controls and reserpinized striata. In addition, the density of both D-1 and D-2 receptors, as measured in binding studies with the selective D-1 antagonist [3H]SCH 23390 and with [3H]spiroperidol respectively, was not affected by the treatment. These results suggest that acute reserpine administration induces a selective up-regulation of the transduction mechanisms associated with D-1 receptors, without changing the functional activity of D-2 receptors.

Original languageEnglish
Pages (from-to)61-64
Number of pages4
JournalNeurochemistry International
Volume14
Issue number1
DOIs
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Cellular and Molecular Neuroscience

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