Abstract
In the present study we investigated the effects of a single injection of reserpine on dopamine receptor function in rat striatum. The measurement of adenylate cyclase activity indicated that cAMP formation induced by the selective D-1 agonist SKF 82526 was greatly increased 2 and 20 h after reserpine; in contrast, the selective D-2 agonist bromocriptine inhibited by the same extent and with the same potency AC in controls and reserpinized striata. In addition, the density of both D-1 and D-2 receptors, as measured in binding studies with the selective D-1 antagonist [3H]SCH 23390 and with [3H]spiroperidol respectively, was not affected by the treatment. These results suggest that acute reserpine administration induces a selective up-regulation of the transduction mechanisms associated with D-1 receptors, without changing the functional activity of D-2 receptors.
| Original language | English |
|---|---|
| Pages (from-to) | 61-64 |
| Number of pages | 4 |
| Journal | Neurochemistry International |
| Volume | 14 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1989 |
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ASJC Scopus subject areas
- Cell Biology
- Molecular Biology
- Cellular and Molecular Neuroscience
Cite this
Differential effect of acute reserpine administration on D-1 and D-2 dopaminergic receptor density and function in rat striatum. / Liberini, Paolo; Nisoli, Enzo; Missale, Cristina; Memo, Maurizio; Buonamici, Matilde; Rossi, Alessandro; Spano, Pier Franco.
In: Neurochemistry International, Vol. 14, No. 1, 1989, p. 61-64.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Differential effect of acute reserpine administration on D-1 and D-2 dopaminergic receptor density and function in rat striatum
AU - Liberini, Paolo
AU - Nisoli, Enzo
AU - Missale, Cristina
AU - Memo, Maurizio
AU - Buonamici, Matilde
AU - Rossi, Alessandro
AU - Spano, Pier Franco
PY - 1989
Y1 - 1989
N2 - In the present study we investigated the effects of a single injection of reserpine on dopamine receptor function in rat striatum. The measurement of adenylate cyclase activity indicated that cAMP formation induced by the selective D-1 agonist SKF 82526 was greatly increased 2 and 20 h after reserpine; in contrast, the selective D-2 agonist bromocriptine inhibited by the same extent and with the same potency AC in controls and reserpinized striata. In addition, the density of both D-1 and D-2 receptors, as measured in binding studies with the selective D-1 antagonist [3H]SCH 23390 and with [3H]spiroperidol respectively, was not affected by the treatment. These results suggest that acute reserpine administration induces a selective up-regulation of the transduction mechanisms associated with D-1 receptors, without changing the functional activity of D-2 receptors.
AB - In the present study we investigated the effects of a single injection of reserpine on dopamine receptor function in rat striatum. The measurement of adenylate cyclase activity indicated that cAMP formation induced by the selective D-1 agonist SKF 82526 was greatly increased 2 and 20 h after reserpine; in contrast, the selective D-2 agonist bromocriptine inhibited by the same extent and with the same potency AC in controls and reserpinized striata. In addition, the density of both D-1 and D-2 receptors, as measured in binding studies with the selective D-1 antagonist [3H]SCH 23390 and with [3H]spiroperidol respectively, was not affected by the treatment. These results suggest that acute reserpine administration induces a selective up-regulation of the transduction mechanisms associated with D-1 receptors, without changing the functional activity of D-2 receptors.
UR - http://www.scopus.com/inward/record.url?scp=0024581998&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024581998&partnerID=8YFLogxK
U2 - 10.1016/0197-0186(89)90010-7
DO - 10.1016/0197-0186(89)90010-7
M3 - Article
AN - SCOPUS:0024581998
VL - 14
SP - 61
EP - 64
JO - Neurochemistry International
JF - Neurochemistry International
SN - 0197-0186
IS - 1
ER -