Differential effect of benzydamine on pro- versus anti-inflammatory cytokine production: Lack of inhibition of interleukin-10 and interleukin-1 receptor antagonist

M. Sironi, L. Massimiliano, P. Transidico, M. Pinza, S. Sozzani, A. Mantovani, A. Vecchi

Research output: Contribution to journalArticlepeer-review

Abstract

The production and action of primary proinflammatory cytokines are strictly controlled by a series of circuits to avoid damage that they can cause if produced in excess. Interleukin-10 and interleukin-1 receptor antagonist contribute to the control of the magnitude of the inflammatory responses in vivo. Benzydamine, a non-steroidal antiinflammatory drug that has been shown to have suppressive activity for the proinflammatory cytokines, tumor necrosis factor-α and interleukin-1β, was investigated for its effects on interleukin-10 and interleukin-1ra production. The drug did not modify the production of interleukin-10 and interleukin-1ra by peripheral blood mononuclear cells stimulated with lipopolysaccharide, under conditions where tumor necrosis factor-α and interleukin-1β were decreased. The antiinflammatory capacity of benzydamine might thus result from its ability to reduce the production of proinflammatory cytokines, without affecting antiinflammatory factors.

Original languageEnglish
Pages (from-to)17-19
Number of pages3
JournalInternational Journal of Clinical & Laboratory Research
Volume30
Issue number1
DOIs
Publication statusPublished - Mar 2000

Keywords

  • Cytokines
  • Interleukin-1 Benzydamine
  • Interleukin-10
  • Non-steroidal antiinflammatory drug

ASJC Scopus subject areas

  • Clinical Biochemistry

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