Differential effect of marrow adiposity and visceral and subcutaneous fat on cardiovascular risk in young, healthy adults

N. Di Iorgi, S. D. Mittelman, V. Gilsanz

Research output: Contribution to journalArticle

Abstract

Background: Adipose tissue is an endocrine organ that influences many metabolic processes and accumulates in different depots, including the bone marrow. While the negative associations between visceral fat (VF) or subcutaneous fat (SF) and cardiovascular disease (CVD) risks are well known, the relation between marrow fat (MF) and metabolic risk is unexplored. Objectives: We examined the relations between these three fat depots and whether CVD risks are associated with marrow adiposity. Design: Observational cross-sectional study. Subjects and methods: Computed tomography was used to measure VF, SF and MF depots in 131 healthy young adults (60 females, 71 males; 16-25 years of age). Weight, body mass index (BMI), waist and hip circumferences, blood pressure (BP), carotid intima-media thickness (CIMT) and serum levels of lipids, glucose and insulin were also measured. Results: Regardless of gender, MF was not associated with values of VF or SF, anthropometric measures, or lipid or carbohydrate serum levels (P>0.05 for all). In contrast, VF was associated with SF (r values=0.74 for females, 0.78 for males; both P-values

Original languageEnglish
Pages (from-to)1854-1860
Number of pages7
JournalInternational Journal of Obesity
Volume32
Issue number12
DOIs
Publication statusPublished - Dec 2008

Keywords

  • Cardiovascular risk
  • Computed tomography
  • Marrow fat
  • Subcutaneous fat
  • Visceral fat

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism

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