Differential effects of ACE-inhibition and angiotensin II antagonism on fibrinolysis and insulin sensitivity in hypertensive postmenopausal women

Roberto Fogari, Annalisa Zoppi, Paola Preti, Elena Fogari, GianDomenico Malamani, Amedeo Mugellini

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to compare the effects of trandolapril and losartan on plasminogen activator inhibitor type 1 (PAI-1) levels and insulin sensitivity in hypertensive postmenopausal women. We studied 89 hypertensive (diastolic blood pressure >90 and 1 antagonists on fibrinolysis and suggest that the PAI-1 decrease induced by angiotensin converting enzyme inhibitors is related to their action on insulin sensitivity and is not dependent on angiotensin II antagonism but rather on other mechanisms. It remains to be seen whether these findings apply to other patient populations than postmenopausal women.

Original languageEnglish
Pages (from-to)921-926
Number of pages6
JournalAmerican Journal of Hypertension
Volume14
Issue number9 I
DOIs
Publication statusPublished - 2001

Keywords

  • Angiotensin converting enzyme inhibitor
  • Angiotensin II antagonist
  • Fibrinolysis
  • Hypertension
  • Insulin sensitivity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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