Differential effects of caffeine on dihydroxyphenylacetic acid concentrations in various rat brain dopaminergic structures

S. Govoni, V. V. Petkov, O. Montefusco, C. Missale, F. Battaini, P. F. Spano, M. Trabucchi

Research output: Contribution to journalArticle

Abstract

The behavioural and neurochemical effects of caffeine were examined in rats. The intraperitoneal administration of different doses of caffeine significantly decreased DOPAC concentrations in striatum, hypothalamus and frontal cortex, but increased them in nucleus accumbens. These observations suggest that the effects of caffeine on the central nervous system (cns) are at least partially mediated through an interaction with the dopaminergic system.

Original languageEnglish
Pages (from-to)458-460
Number of pages3
JournalJournal of Pharmacy and Pharmacology
Volume36
Issue number7
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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    Govoni, S., Petkov, V. V., Montefusco, O., Missale, C., Battaini, F., Spano, P. F., & Trabucchi, M. (1984). Differential effects of caffeine on dihydroxyphenylacetic acid concentrations in various rat brain dopaminergic structures. Journal of Pharmacy and Pharmacology, 36(7), 458-460.