Differential effects of lactate and H+ on performance and metabolism in the rat heart

M. Samaja, S. Allibardi, G. Milano, G. Neri, B. Grassi, L. B. Gladden, M. C. Hogan

Research output: Contribution to journalArticle

Abstract

Although the effects of both high [H+] and high [lactate] ([L-]) are receiving attention under ischemia-reperfusion conditions, little is known about their effects in non-ischemic hearts. Isolated rat hearts were Langendorff-perfused at constant, unlimiting flow with media at two pH (7.4 and 7.0) and two [L-] (0 and 20 mM) in various sequences (n=6/group). We measured contractility, O2 uptake, diastolic pressure, and at the end of the protocol, tissue [L-] and pH. Perfusion with high [L-] raised tissue [L-] from 5.5±0.1 to 17.5±2.6 μmoles/heart (P

Original languageEnglish
JournalFASEB Journal
Volume12
Issue number5
Publication statusPublished - Mar 20 1998

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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    Samaja, M., Allibardi, S., Milano, G., Neri, G., Grassi, B., Gladden, L. B., & Hogan, M. C. (1998). Differential effects of lactate and H+ on performance and metabolism in the rat heart. FASEB Journal, 12(5).