Differential effects of lactate and H+ on performance and metabolism in the rat heart

M. Samaja; S. Allibardi; G. Milano; G. Neri; B. Grassi; L. B. Gladden; M. C. Hogan

Differential effects of lactate and H+ on performance and metabolism in the rat heart

M. Samaja, S. Allibardi, G. Milano, G. Neri, B. Grassi, L. B. Gladden, M. C. Hogan

Centro Cardiologico Monzino

Research output: Contribution to journal › Article › peer-review

Abstract

Although the effects of both high [H+] and high [lactate] ([L-]) are receiving attention under ischemia-reperfusion conditions, little is known about their effects in non-ischemic hearts. Isolated rat hearts were Langendorff-perfused at constant, unlimiting flow with media at two pH (7.4 and 7.0) and two [L-] (0 and 20 mM) in various sequences (n=6/group). We measured contractility, O2 uptake, diastolic pressure, and at the end of the protocol, tissue [L-] and pH. Perfusion with high [L-] raised tissue [L-] from 5.5±0.1 to 17.5±2.6 μmoles/heart (P

Original language	English
Journal	FASEB Journal
Volume	12
Issue number	5
Publication status	Published - Mar 20 1998

ASJC Scopus subject areas

Agricultural and Biological Sciences (miscellaneous)
Biochemistry, Genetics and Molecular Biology(all)
Biochemistry
Cell Biology

Cite this

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T1 - Differential effects of lactate and H+ on performance and metabolism in the rat heart

AU - Samaja, M.

AU - Allibardi, S.

AU - Milano, G.

AU - Neri, G.

AU - Grassi, B.

AU - Gladden, L. B.

AU - Hogan, M. C.

PY - 1998/3/20

Y1 - 1998/3/20

N2 - Although the effects of both high [H+] and high [lactate] ([L-]) are receiving attention under ischemia-reperfusion conditions, little is known about their effects in non-ischemic hearts. Isolated rat hearts were Langendorff-perfused at constant, unlimiting flow with media at two pH (7.4 and 7.0) and two [L-] (0 and 20 mM) in various sequences (n=6/group). We measured contractility, O2 uptake, diastolic pressure, and at the end of the protocol, tissue [L-] and pH. Perfusion with high [L-] raised tissue [L-] from 5.5±0.1 to 17.5±2.6 μmoles/heart (P

AB - Although the effects of both high [H+] and high [lactate] ([L-]) are receiving attention under ischemia-reperfusion conditions, little is known about their effects in non-ischemic hearts. Isolated rat hearts were Langendorff-perfused at constant, unlimiting flow with media at two pH (7.4 and 7.0) and two [L-] (0 and 20 mM) in various sequences (n=6/group). We measured contractility, O2 uptake, diastolic pressure, and at the end of the protocol, tissue [L-] and pH. Perfusion with high [L-] raised tissue [L-] from 5.5±0.1 to 17.5±2.6 μmoles/heart (P

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Differential effects of lactate and H+ on performance and metabolism in the rat heart

Abstract

ASJC Scopus subject areas

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