Differential effects of lithium on platelet protein phosphorylation in bipolar patients and healthy subjects

Raffaella Zanardi, Giorgio Racagni, Enrico Smeraldi, Jorge Perez

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

In the present study we have investigated the cAMP-dependent phosphorylation system in platelets of euthymic bipolar patients and healthy volunteers before and after 15 days of lithium treatment. The results showed that 15 days of lithium treatment enhanced the basal and the cAMP-stimulated 32P incorporation in the 22 and 38 kDa phosphoproteins in bipolar patients, but not in healthy subjects. Moreover, we provided further evidence of increased phosphorylation in the 22 kDa platelet phosphoprotein in untreated euthymic bipolar patients when compared with controls. Overall, these findings suggest an implication of protein phosphorylation in the biochemical action of lithium and in the pathophysiology of bipolar disorder.

Original languageEnglish
Pages (from-to)44-47
Number of pages4
JournalPsychopharmacology
Volume129
Issue number1
DOIs
Publication statusPublished - 1997

Fingerprint

Lithium
Healthy Volunteers
Blood Platelets
Phosphoproteins
Phosphorylation
Proteins
Bipolar Disorder
Therapeutics

Keywords

  • bipolar disorder
  • lithium
  • platelet
  • protein phosphorylation

ASJC Scopus subject areas

  • Pharmacology

Cite this

Differential effects of lithium on platelet protein phosphorylation in bipolar patients and healthy subjects. / Zanardi, Raffaella; Racagni, Giorgio; Smeraldi, Enrico; Perez, Jorge.

In: Psychopharmacology, Vol. 129, No. 1, 1997, p. 44-47.

Research output: Contribution to journalArticle

Zanardi, Raffaella ; Racagni, Giorgio ; Smeraldi, Enrico ; Perez, Jorge. / Differential effects of lithium on platelet protein phosphorylation in bipolar patients and healthy subjects. In: Psychopharmacology. 1997 ; Vol. 129, No. 1. pp. 44-47.
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