Abstract
In the present study we have investigated the cAMP-dependent phosphorylation system in platelets of euthymic bipolar patients and healthy volunteers before and after 15 days of lithium treatment. The results showed that 15 days of lithium treatment enhanced the basal and the cAMP-stimulated 32P incorporation in the 22 and 38 kDa phosphoproteins in bipolar patients, but not in healthy subjects. Moreover, we provided further evidence of increased phosphorylation in the 22 kDa platelet phosphoprotein in untreated euthymic bipolar patients when compared with controls. Overall, these findings suggest an implication of protein phosphorylation in the biochemical action of lithium and in the pathophysiology of bipolar disorder.
| Original language | English |
|---|---|
| Pages (from-to) | 44-47 |
| Number of pages | 4 |
| Journal | Psychopharmacology |
| Volume | 129 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1997 |
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Keywords
- bipolar disorder
- lithium
- platelet
- protein phosphorylation
ASJC Scopus subject areas
- Pharmacology
Cite this
Differential effects of lithium on platelet protein phosphorylation in bipolar patients and healthy subjects. / Zanardi, Raffaella; Racagni, Giorgio; Smeraldi, Enrico; Perez, Jorge.
In: Psychopharmacology, Vol. 129, No. 1, 1997, p. 44-47.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Differential effects of lithium on platelet protein phosphorylation in bipolar patients and healthy subjects
AU - Zanardi, Raffaella
AU - Racagni, Giorgio
AU - Smeraldi, Enrico
AU - Perez, Jorge
PY - 1997
Y1 - 1997
N2 - In the present study we have investigated the cAMP-dependent phosphorylation system in platelets of euthymic bipolar patients and healthy volunteers before and after 15 days of lithium treatment. The results showed that 15 days of lithium treatment enhanced the basal and the cAMP-stimulated 32P incorporation in the 22 and 38 kDa phosphoproteins in bipolar patients, but not in healthy subjects. Moreover, we provided further evidence of increased phosphorylation in the 22 kDa platelet phosphoprotein in untreated euthymic bipolar patients when compared with controls. Overall, these findings suggest an implication of protein phosphorylation in the biochemical action of lithium and in the pathophysiology of bipolar disorder.
AB - In the present study we have investigated the cAMP-dependent phosphorylation system in platelets of euthymic bipolar patients and healthy volunteers before and after 15 days of lithium treatment. The results showed that 15 days of lithium treatment enhanced the basal and the cAMP-stimulated 32P incorporation in the 22 and 38 kDa phosphoproteins in bipolar patients, but not in healthy subjects. Moreover, we provided further evidence of increased phosphorylation in the 22 kDa platelet phosphoprotein in untreated euthymic bipolar patients when compared with controls. Overall, these findings suggest an implication of protein phosphorylation in the biochemical action of lithium and in the pathophysiology of bipolar disorder.
KW - bipolar disorder
KW - lithium
KW - platelet
KW - protein phosphorylation
UR - http://www.scopus.com/inward/record.url?scp=0031022814&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031022814&partnerID=8YFLogxK
U2 - 10.1007/s002130050160
DO - 10.1007/s002130050160
M3 - Article
VL - 129
SP - 44
EP - 47
JO - Psychopharmacology
JF - Psychopharmacology
SN - 0033-3158
IS - 1
ER -