Differential effects of short-term or prolonged cocaine exposure on peripheral blood cells in mice

Paolo Di Francesco, Roberto Falchetti, Roberta Gaziano, Giulia Lanzilli, Luisella Belogi, Giampietro Ravagnan, Enrico Garaci

Research output: Contribution to journalArticle

Abstract

The effects of cocaine on the number of murine peripheral blood cells and on phenotypic expression of lymphocyte subsets were examined using different regimens of drug exposure. Cocaine administered to mice for 7 consecutive days at 1 and 10 mg/kg/day reduced the absolute number of circulating white blood cells and the relative number of cells stained as lymphocytes, polymorphonuclear cells and monocytes. Cocaine did not modify the relative proportion between lymphocytes, polymorphonuclear cells and monocytes. Parallely, there were no changes in the percentage of circulating CD4+ and CD8+ lymphocytes, while the number of natural killer cells increased. In sharp contrast, we didn't observe any significant change in peripheral blood cells after 30 days of consecutive drug administrations.

Original languageEnglish
Pages (from-to)2015-2020
Number of pages6
JournalLife Sciences
Volume54
Issue number25
DOIs
Publication statusPublished - 1994

Fingerprint

Lymphocytes
Cocaine
Blood Cells
Blood
Cells
Monocytes
Blood Cell Count
Lymphocyte Subsets
Lymphocyte Count
Natural Killer Cells
Pharmaceutical Preparations
Leukocytes

Keywords

  • cocaine
  • immune system
  • neuroimmunomodulation

ASJC Scopus subject areas

  • Pharmacology

Cite this

Di Francesco, P., Falchetti, R., Gaziano, R., Lanzilli, G., Belogi, L., Ravagnan, G., & Garaci, E. (1994). Differential effects of short-term or prolonged cocaine exposure on peripheral blood cells in mice. Life Sciences, 54(25), 2015-2020. https://doi.org/10.1016/0024-3205(94)90136-8

Differential effects of short-term or prolonged cocaine exposure on peripheral blood cells in mice. / Di Francesco, Paolo; Falchetti, Roberto; Gaziano, Roberta; Lanzilli, Giulia; Belogi, Luisella; Ravagnan, Giampietro; Garaci, Enrico.

In: Life Sciences, Vol. 54, No. 25, 1994, p. 2015-2020.

Research output: Contribution to journalArticle

Di Francesco, P, Falchetti, R, Gaziano, R, Lanzilli, G, Belogi, L, Ravagnan, G & Garaci, E 1994, 'Differential effects of short-term or prolonged cocaine exposure on peripheral blood cells in mice', Life Sciences, vol. 54, no. 25, pp. 2015-2020. https://doi.org/10.1016/0024-3205(94)90136-8
Di Francesco P, Falchetti R, Gaziano R, Lanzilli G, Belogi L, Ravagnan G et al. Differential effects of short-term or prolonged cocaine exposure on peripheral blood cells in mice. Life Sciences. 1994;54(25):2015-2020. https://doi.org/10.1016/0024-3205(94)90136-8
Di Francesco, Paolo ; Falchetti, Roberto ; Gaziano, Roberta ; Lanzilli, Giulia ; Belogi, Luisella ; Ravagnan, Giampietro ; Garaci, Enrico. / Differential effects of short-term or prolonged cocaine exposure on peripheral blood cells in mice. In: Life Sciences. 1994 ; Vol. 54, No. 25. pp. 2015-2020.
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