Differential effects of short-term or prolonged cocaine exposure on peripheral blood cells in mice

Paolo Di Francesco, Roberto Falchetti, Roberta Gaziano, Giulia Lanzilli, Luisella Belogi, Giampietro Ravagnan, Enrico Garaci

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of cocaine on the number of murine peripheral blood cells and on phenotypic expression of lymphocyte subsets were examined using different regimens of drug exposure. Cocaine administered to mice for 7 consecutive days at 1 and 10 mg/kg/day reduced the absolute number of circulating white blood cells and the relative number of cells stained as lymphocytes, polymorphonuclear cells and monocytes. Cocaine did not modify the relative proportion between lymphocytes, polymorphonuclear cells and monocytes. Parallely, there were no changes in the percentage of circulating CD4+ and CD8+ lymphocytes, while the number of natural killer cells increased. In sharp contrast, we didn't observe any significant change in peripheral blood cells after 30 days of consecutive drug administrations.

Original languageEnglish
Pages (from-to)2015-2020
Number of pages6
JournalLife Sciences
Volume54
Issue number25
DOIs
Publication statusPublished - 1994

Keywords

  • cocaine
  • immune system
  • neuroimmunomodulation

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Differential effects of short-term or prolonged cocaine exposure on peripheral blood cells in mice'. Together they form a unique fingerprint.

Cite this