Differential effects on CLL cell survival exerted by different microenvironmental elements

P. Ghia, P. Circosta, C. Scielzo, A. Vallario, A. Camporeale, L. Granziero, F. Caligaris-Cappio

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Abstract

Selected microenvironmental stimuli confer to leukemic cells a growth advantage and an extended survival. We aimed at dissecting the differential support provided by the different cellular components of the microenvironment where CLL cells accumulate. To this end we cultured purified CLL cells in vitro in the presence or absence of different accessory cells (stromal cells, autologous T lymphocytes) and/or soluble molecules (IL-4, sCD40L) and assessed the leukemic cell response in terms of cell viability and chemoattracting capacity. The results indicate that both T lymphocytes and stromal cells are involved in sustaining the survival of leukemic B cells, but indicate that their support is different in terms of time of onset and duration. T cells have a short-term support activity while stromal cells provide long-term support.

Original languageEnglish
Pages (from-to)135-145
Number of pages11
JournalCurrent Topics in Microbiology and Immunology
Volume294
Publication statusPublished - 2005

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology (medical)
  • Immunology and Microbiology(all)
  • Microbiology

Cite this

Ghia, P., Circosta, P., Scielzo, C., Vallario, A., Camporeale, A., Granziero, L., & Caligaris-Cappio, F. (2005). Differential effects on CLL cell survival exerted by different microenvironmental elements. Current Topics in Microbiology and Immunology, 294, 135-145.