Differential expression of BCL-6, CD138/syndecan-1, and Epstein-Barr virus-encoded latent membrane protein-1 identifies distinct histogenetic subsets of acquired immunodeficiency syndrome-related non-Hodgkin's lymphomas

Antonino Carbone, Gianluca Gaidano, Annunziata Gloghini, Luigi M. Larocca, Daniela Capello, Vincenzo Canzonieri, Andrea Antinori, Umberto Tirelli, Brunangelo Falini, Riccardo Dalla-Favera

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Abstract

This study was aimed at defining the histogenesis of the pathologic spectrum of acquired immunodeficiency syndrome-related non-Hodgkin's lymphomas (AIDS-NHL), including AIDS-related small noncleaved cell lymphoma (AIDS-SNCCL), AIDS-related large noncleaved cell lymphoma (AIDS-LNCCL), AIDS- related large cell immunoblastic lymphoma plasmacytoid (AIDS-IBLP), and AIDS- related primary effusion lymphoma (AIDS-PEL). Forty-six cases of AIDS-NHL were investigated for the expression pattern of BCL-6, a protein specifically expressed by germinal canter (GC) B-cells, and CD138/syndecan-1 (syn-1), a marker of post-GC B-cell differentiation. Expression of BCL-6 and syn-1 segregated two major phenotypic patterns among AIDS-NHL: (1) the BCL-6+/syn- 1- pattern associated with AIDS-SNCCL and AIDS-LNCCL; (2) the BCL-6-/syn- 1+ pattern associated with AIDS-IBLP and AIDS-PEL. Among systemic AIDS-NHL infected by Epstein-Barr virus (EBV), expression of the EBV-encoded latent membrane protein-1 (LMP-1) preferentially associated with the BCL-6-/syn- 1+ profile. Analysis of nonneoplastic lymph nodes showed that the two phenotypic patterns detected in AIDS-NHL correspond to physiologic stages of B-cell development, is, GC B-cells (BCL-6+/syn-1-) and preterminally differentiated post-GC B-cells (BCL6-/syn-1+). Thus, BCL-6+/syn-1- AIDS- NHL reflects a GC stage of differentiation, whereas AIDS-NHL which are BCL- 6-/syn-1+, and LMP-1+ when infected by EBV, derive from B cells that have entered post-GC plasma-cell differentiation. These findings are relevant for the pathogenesis and differential diagnosis of AIDS-NHL.

Original languageEnglish
Pages (from-to)747-755
Number of pages9
JournalBlood
Volume91
Issue number3
Publication statusPublished - Feb 1 1998

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Syndecan-1
Viruses
Non-Hodgkin's Lymphoma
Membrane Proteins
Acquired Immunodeficiency Syndrome
Cells
AIDS-Related Lymphoma
B-Lymphocytes
Primary Effusion Lymphoma
Human Herpesvirus 4
Epstein-Barr virus EBV-associated membrane antigen
Cell Differentiation
Lymphoma
Large-Cell Immunoblastic Lymphoma
Plasmas
Plasma Cells

ASJC Scopus subject areas

  • Hematology

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Differential expression of BCL-6, CD138/syndecan-1, and Epstein-Barr virus-encoded latent membrane protein-1 identifies distinct histogenetic subsets of acquired immunodeficiency syndrome-related non-Hodgkin's lymphomas. / Carbone, Antonino; Gaidano, Gianluca; Gloghini, Annunziata; Larocca, Luigi M.; Capello, Daniela; Canzonieri, Vincenzo; Antinori, Andrea; Tirelli, Umberto; Falini, Brunangelo; Dalla-Favera, Riccardo.

In: Blood, Vol. 91, No. 3, 01.02.1998, p. 747-755.

Research output: Contribution to journalArticle

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abstract = "This study was aimed at defining the histogenesis of the pathologic spectrum of acquired immunodeficiency syndrome-related non-Hodgkin's lymphomas (AIDS-NHL), including AIDS-related small noncleaved cell lymphoma (AIDS-SNCCL), AIDS-related large noncleaved cell lymphoma (AIDS-LNCCL), AIDS- related large cell immunoblastic lymphoma plasmacytoid (AIDS-IBLP), and AIDS- related primary effusion lymphoma (AIDS-PEL). Forty-six cases of AIDS-NHL were investigated for the expression pattern of BCL-6, a protein specifically expressed by germinal canter (GC) B-cells, and CD138/syndecan-1 (syn-1), a marker of post-GC B-cell differentiation. Expression of BCL-6 and syn-1 segregated two major phenotypic patterns among AIDS-NHL: (1) the BCL-6+/syn- 1- pattern associated with AIDS-SNCCL and AIDS-LNCCL; (2) the BCL-6-/syn- 1+ pattern associated with AIDS-IBLP and AIDS-PEL. Among systemic AIDS-NHL infected by Epstein-Barr virus (EBV), expression of the EBV-encoded latent membrane protein-1 (LMP-1) preferentially associated with the BCL-6-/syn- 1+ profile. Analysis of nonneoplastic lymph nodes showed that the two phenotypic patterns detected in AIDS-NHL correspond to physiologic stages of B-cell development, is, GC B-cells (BCL-6+/syn-1-) and preterminally differentiated post-GC B-cells (BCL6-/syn-1+). Thus, BCL-6+/syn-1- AIDS- NHL reflects a GC stage of differentiation, whereas AIDS-NHL which are BCL- 6-/syn-1+, and LMP-1+ when infected by EBV, derive from B cells that have entered post-GC plasma-cell differentiation. These findings are relevant for the pathogenesis and differential diagnosis of AIDS-NHL.",
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AU - Gaidano, Gianluca

AU - Gloghini, Annunziata

AU - Larocca, Luigi M.

AU - Capello, Daniela

AU - Canzonieri, Vincenzo

AU - Antinori, Andrea

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AU - Falini, Brunangelo

AU - Dalla-Favera, Riccardo

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