Differential expression of galectin 3 in solid cell nests and C cells of human thyroid

A. Faggiano, M. Talbot, E. Baudin, J. M. Bidart, M. Schlumberger, B. Caillou

Research output: Contribution to journalArticle

Abstract

Aims: To provide new insights into characterising solid cell nests and gain information that might help distinguish between solid cell nests and C cells. Methods: Thyroid tissue specimens from patients who had undergone prophylactic thyroidectomy for familial medullary thyroid cancer were immunostained for calcitonin, carcinoembryonic antigen, and galectin 3. Results: Solid cell nests displayed a strong and diffuse staining for carcinoembryonic antigen and galectin 3, but not for calcitonin. C cells located at the periphery of solid cell nests and in neighbouring follicles expressed both calcitonin and carcinoembryonic antigen but not galectin 3. These three marker's were positive in medullary thyroid carcinoma. Conclusion: Galectin 3 immunoreactivity permits a better characterisation and differentiation between solid cell nests and C cells, avoiding the misidentification of two biologically and clinically different thyroid structures.

Original languageEnglish
Pages (from-to)142-143
Number of pages2
JournalJournal of Clinical Pathology
Volume56
Issue number2
DOIs
Publication statusPublished - Feb 1 2003

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Faggiano, A., Talbot, M., Baudin, E., Bidart, J. M., Schlumberger, M., & Caillou, B. (2003). Differential expression of galectin 3 in solid cell nests and C cells of human thyroid. Journal of Clinical Pathology, 56(2), 142-143. https://doi.org/10.1136/jcp.56.2.142