Differential expression of synaptophysin and synaptoporin mRNAs in the postnatal rat central nervous system

B. Marqueze-Pouey, W. Wisden, M. L. Malosio, H. Betz

Research output: Contribution to journalArticle

Abstract

Synaptophysin and synaptoporin are two homologous integral membrane proteins of small synaptic vesicles. Here, the distribution of the corresponding transcripts in the CNS of the rat was investigated by in situ hybridization using sequence-specific oligonucleotide probes. Synaptophysin mRNA was abundantly distributed through all major brain regions, whereas synaptoporin transcripts displayed a more restricted localization in telencephalic structures. Resolution at the cellular level disclosed a differential labeling of distinct cell types in different areas, suggesting that synaptophysin and synaptoporin are expressed by specific subpopulations of central neurons. Consistent with this conclusion, relative synaptoporin mRNA contents were found to vary between different brain regions during postnatal development, whereas synaptophysin transcripts showed a more uniform increase during the same period.

Original languageEnglish
Pages (from-to)3388-3397
Number of pages10
JournalJournal of Neuroscience
Volume11
Issue number11
Publication statusPublished - 1991

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Synaptophysin
Central Nervous System
Messenger RNA
Telencephalon
Oligonucleotide Probes
Synaptic Vesicles
Brain
In Situ Hybridization
Membrane Proteins
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Differential expression of synaptophysin and synaptoporin mRNAs in the postnatal rat central nervous system. / Marqueze-Pouey, B.; Wisden, W.; Malosio, M. L.; Betz, H.

In: Journal of Neuroscience, Vol. 11, No. 11, 1991, p. 3388-3397.

Research output: Contribution to journalArticle

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