Abstract
We studied non-small cell lung cancers (NSCLC) from 60 patients for abnormalities in the c-erbB-2 gene. Eleven human lung cancer cell lines, including four derived from small cell lung cancer (SCLC) and seven derived from NSCLC were also examined for altered c-erbB-2 gene expression. Southern blot analysis of paired tumor and normal lung samples demonstrated that amplification of the c-erbB-2 gene is rare in NSCLC (2/60) and not restricted to adenocarcinomas. One patient showed an EcoRI restriction fragment length polymorphism for the cerbB-2 locus. Four of four SCLC cell lines demonstrated minimal or nondetectable expression of c-erbB-2 mRNA compared to high levels of expression by seven of seven NSCLC lines. The highest expression levels were seen in four of four adenocarcinomas. We conclude that c-erbB-2 expression is different in SCLC compared to NSCLC and high expression ofc-erbB-2 is consistently present in lung adenocarcinomas.
Original language | English |
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Pages (from-to) | 4968-4971 |
Number of pages | 4 |
Journal | Cancer Research |
Volume | 49 |
Issue number | 18 |
Publication status | Published - Sep 15 1989 |
ASJC Scopus subject areas
- Oncology
- Cancer Research