Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation

Maurizio Pesce, Xiangyuan Wang, Debra J. Wolgemuth, Hans R. Schöler

Research output: Contribution to journalArticle

375 Citations (Scopus)

Abstract

The POU transcription factor Oct-4 is expressed in early mouse embryogenesis and in pluripotent embryonic stem (ES) and embryonic carcinoma (EC) stem cell lines. After gastrulation in the embryo, Oct-4 expression is confined to the germline. The present study provides evidence that Oct-4 undergoes downregulation during oogenesis and spermatogenesis, coincident with entry into meiosis. Furthermore, analysis of maturation stages of oocytes showed that Oct-4 is upregulated de novo in the final stages of meiotic prophase I in female germ cells. These data suggest that Oct-4 downregulation in germ cells in both sexes might represent one of the molecular triggers involved in the commitment to meiosis. The upregulation of Oct-4 in oocytes at the completion of the prophase I of meiotic division further suggests a specific involvement of this transcription factor in oocyte growth or the acquisition of meiotic competence.

Original languageEnglish
Pages (from-to)89-98
Number of pages10
JournalMechanisms of Development
Volume71
Issue number1-2
DOIs
Publication statusPublished - Feb 1998

Fingerprint

Octamer Transcription Factor-3
Germ Cells
Meiotic Prophase I
Oocytes
Cell Differentiation
Meiosis
Down-Regulation
Oogenesis
Gastrulation
Spermatogenesis
Embryonic Stem Cells
Mental Competency
Embryonic Development
Transcription Factors
Up-Regulation
Embryonic Structures
Carcinoma
Cell Line
Growth

Keywords

  • Germ cells
  • Meiosis
  • Mouse gonad
  • Oct-4
  • Oogenesis
  • Primordial germ cells
  • Spermatogenesis

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation. / Pesce, Maurizio; Wang, Xiangyuan; Wolgemuth, Debra J.; Schöler, Hans R.

In: Mechanisms of Development, Vol. 71, No. 1-2, 02.1998, p. 89-98.

Research output: Contribution to journalArticle

Pesce, Maurizio ; Wang, Xiangyuan ; Wolgemuth, Debra J. ; Schöler, Hans R. / Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation. In: Mechanisms of Development. 1998 ; Vol. 71, No. 1-2. pp. 89-98.
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