Differential expression pattern of XqPAR-linked genes SYBL1 and IL9R correlates with the structure and evolution of the region

Maurizio D'Esposito, Maria Rosaria Matarazzo, Alfredo Ciccodicola, Maria Strazzullo, Richard Mazzarella, Nandita A. Quaderi, Hiroyuki Fujiwara, Minoru S H Ko, Lucy B. Rowe, Angela Ricco, Nicoletta Archidiacono, Mariano Rocchi, David Schlessinger, Michele D'Urso

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Abstract

The recently discovered second pseudoautosomal region (XqPAR) contains at least two genes, IL9R and SYBL1. Recent findings show that, like XpPAR genes, IL9R escapes X inactivation and its Y allele is also expressed, but SYBL1 seems to act like an X-linked gene, expressed from the active X chromosome but not from the inactive X or Y. Here we show that differences are also seen in the evolution of the sex chromosome locations of IL9R and SYBL1, IL9R is known to be autosomal in mice, and is X-linked only in primates. SYBL1, however, has been found to be on the X chromosome in all mammals tested, from marsupials to humans. Both genes were duplicated on the Y homologue of the terminal portion of the X chromosome during the evolution of Homo sapiens from other higher primates. The inactivation pattern of SYBL1 may be correlated with its longer history of X linkage, and at a more centromeric chromosomal position during evolution; the more recent X linkage and more telomeric position of the IL9R gene may explain its autosomal, 'uninactivated' transcriptional status.

Original languageEnglish
Pages (from-to)1917-1923
Number of pages7
JournalHuman Molecular Genetics
Volume6
Issue number11
DOIs
Publication statusPublished - Oct 1997

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X Chromosome
Primates
Genes
Marsupialia
X Chromosome Inactivation
X-Linked Genes
Sex Chromosomes
Gene Order
Mammals
Alleles

ASJC Scopus subject areas

  • Genetics

Cite this

Differential expression pattern of XqPAR-linked genes SYBL1 and IL9R correlates with the structure and evolution of the region. / D'Esposito, Maurizio; Matarazzo, Maria Rosaria; Ciccodicola, Alfredo; Strazzullo, Maria; Mazzarella, Richard; Quaderi, Nandita A.; Fujiwara, Hiroyuki; Ko, Minoru S H; Rowe, Lucy B.; Ricco, Angela; Archidiacono, Nicoletta; Rocchi, Mariano; Schlessinger, David; D'Urso, Michele.

In: Human Molecular Genetics, Vol. 6, No. 11, 10.1997, p. 1917-1923.

Research output: Contribution to journalArticle

D'Esposito, M, Matarazzo, MR, Ciccodicola, A, Strazzullo, M, Mazzarella, R, Quaderi, NA, Fujiwara, H, Ko, MSH, Rowe, LB, Ricco, A, Archidiacono, N, Rocchi, M, Schlessinger, D & D'Urso, M 1997, 'Differential expression pattern of XqPAR-linked genes SYBL1 and IL9R correlates with the structure and evolution of the region', Human Molecular Genetics, vol. 6, no. 11, pp. 1917-1923. https://doi.org/10.1093/hmg/6.11.1917
D'Esposito, Maurizio ; Matarazzo, Maria Rosaria ; Ciccodicola, Alfredo ; Strazzullo, Maria ; Mazzarella, Richard ; Quaderi, Nandita A. ; Fujiwara, Hiroyuki ; Ko, Minoru S H ; Rowe, Lucy B. ; Ricco, Angela ; Archidiacono, Nicoletta ; Rocchi, Mariano ; Schlessinger, David ; D'Urso, Michele. / Differential expression pattern of XqPAR-linked genes SYBL1 and IL9R correlates with the structure and evolution of the region. In: Human Molecular Genetics. 1997 ; Vol. 6, No. 11. pp. 1917-1923.
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