TY - JOUR
T1 - Differential IL-17 production and mannan recognition contribute to fungal pathogenicity and commensalism
AU - Rizzetto, Lisa
AU - Kuka, Mirela
AU - De Filippo, Carlotta
AU - Cambi, Alessandra
AU - Netea, Mihai G.
AU - Beltrame, Luca
AU - Napolitani, Giorgio
AU - Torcia, Maria Gabriella
AU - D'Oro, Ugo
AU - Cavalieri, Duccio
PY - 2010/4/15
Y1 - 2010/4/15
N2 - In this study, we present evidence of differential Th17 responses in human monocyte-derived dendritic cells exposed to the pathogenic Candida albicans or the nonpathogenic Saccharomyces cerevisiae.We use different forms of the microorganisms, cells, hyphae, and spores, as a toolbox to dissect the role of surface mannan in the fungal immune response. In contrast to the S. cerevisiae yeast cellinduced Th1 response, dendritic cells stimulated with spores or C. albicans hyphae induce cellular responses shifted toward Th17 differentiation. The differential recognition of specific mannan structures is the master regulator of the discrimination between harmful and harmless fungi. The switch between spores and yeast is crucial for the commensalism of S. cerevisiae and depends on the use of a different receptor repertoire. Understanding the role of cell wall recognition during infection might lead to understanding the boundaries between safety and pathogenicity.
AB - In this study, we present evidence of differential Th17 responses in human monocyte-derived dendritic cells exposed to the pathogenic Candida albicans or the nonpathogenic Saccharomyces cerevisiae.We use different forms of the microorganisms, cells, hyphae, and spores, as a toolbox to dissect the role of surface mannan in the fungal immune response. In contrast to the S. cerevisiae yeast cellinduced Th1 response, dendritic cells stimulated with spores or C. albicans hyphae induce cellular responses shifted toward Th17 differentiation. The differential recognition of specific mannan structures is the master regulator of the discrimination between harmful and harmless fungi. The switch between spores and yeast is crucial for the commensalism of S. cerevisiae and depends on the use of a different receptor repertoire. Understanding the role of cell wall recognition during infection might lead to understanding the boundaries between safety and pathogenicity.
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U2 - 10.4049/jimmunol.0902972
DO - 10.4049/jimmunol.0902972
M3 - Article
C2 - 20228201
AN - SCOPUS:77952766743
VL - 184
SP - 4258
EP - 4268
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 8
ER -