Differential in situ expression of IL-17 in skin diseases

Mattias Fischer-Stabauer, Alexander Boehner, Stefanie Eyerich, Teresa Carbone, Claudia Traidl-Hoffmann, Carsten B. Schmidt-Weber, Andrea Cavani, Johannes Ring, Ruediger Hein, Kilian Eyerich

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Interleukin (IL)-17 is a key molecule for epithelial immunity and inflammation. Objectives: To quantify IL-17 expression in situ in a large panel of cutaneous diseases. Materials&Methods: 289 samples of the 30 most common cutaneous infectious, autoimmune, inflammatory and tumor diseases were stained for IL-17 immunohistochemically. Results: IL-17 expression strongly varied between the diseases, but was conserved within each disease. The major cellular sources of IL-17 were T cells and granulocytes. Skin diseases caused by extracellular microbials were infiltrated by many IL-17+ cells, while intracellular infections were scarcely positive for IL-17. While autoimmune diseases were mostly accompanied by IL-17+ T cells, IL-17+ granulocytes were dominant in neutrophilic dermatoses. Conclusion: Cutaneous diseases show a characteristic pattern of IL-17+ cellular infiltrate. These patterns are relevant for the clinician, since therapeutic approaches targeting differentiation of Th17 cells as well as direct targeting of IL-17 are or will become available.

Original languageEnglish
Pages (from-to)781-784
Number of pages4
JournalEuropean Journal of Dermatology
Volume22
Issue number6
DOIs
Publication statusPublished - Dec 2012

Keywords

  • Interleukin (IL)-17
  • Neutrophil granulocyte
  • T cell
  • Th17

ASJC Scopus subject areas

  • Dermatology

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