Differential integrin expression in thyroid and laryngeal carcinomas

Maria Teresa Carlevato, Livio Trusolino, Guido Serini, Guido Valente, Fabio Orlandi, Alberto Angeli, Giorgio Cortesina, Pier Carlo Marchisio

Research output: Contribution to journalArticlepeer-review


Several laryngeal and thyroid carcinomas were studied immunohistochemically to evaluate whether the expression and distribution of integrins and basal lamina components can represent reproducible markers for correct diagnosis and prognosis. In laryngeal cancers, the depolarization and pericellular redistribution of α3β1 and α6β4, and focal or fragmentation of the basal lamina, according to tumor prognosis, occurred. In thyroid carcinomas, loss of polar topography of α3β1 and neo-expression of α6β4 in histopathologically or clinically aggressive cancers were observed. Therefore, the addition of a panel of adhesion molecules to the toolbox of surgical pathologists may improve diagnostic and prognostic procedures.

Original languageEnglish
Pages (from-to)2379-2384
Number of pages6
JournalAnticancer Research
Issue number4 C
Publication statusPublished - Jul 1996


  • Adhesion molecules
  • Integrins
  • Laryngeal cancer
  • Thyroid cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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